About Tissue-resident T-cell transcription regulator protein ZNF683
Tissue-resident T-cell transcription regulator protein ZNF683 (ZNF683) is a protein
from Homo sapiens identified by UniProt accession
Q8IZ20, 524 residues long.
MolForge cross-references it against 0 known binders and
70 disease associations.
Target properties
| Protein name | Tissue-resident T-cell transcription regulator protein ZNF683 |
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| UniProt accession | Q8IZ20 |
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| Gene | ZNF683 |
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| Organism | Homo sapiens |
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| Length | 524 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (70)
Diseases linked to this target (Open Targets).
- PR interval · score 0.15
- Miyoshi myopathy · score 0.07
- cancer · score 0.07
- isolated agammaglobulinemia · score 0.06
- combined immunodeficiency with skin granulomas · score 0.05
- agammaglobulinemia 7, autosomal recessive · score 0.05
- common variable immunodeficiency · score 0.05
- immunodeficiency 18 · score 0.05
- severe combined immunodeficiency due to IKK2 deficiency · score 0.04
- monocyte count · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IZ20-F1 | alphafold | PREDICTED | 49.28 | — |
Amino-acid sequence (524 residues)
MKEESAAQLG CCHRPMALGG TGGSLSPSLD FQLFRGDQVF SACRPLPDMV DAHGPSCASW LCPLPLAPGR SALLACLQDL DLNLCTPQPA PLGTDLQGLQ EDALSMKHEP PGLQASSTDD KKFTVKYPQN KDKLGKQPER AGEGAPCPAF SSHNSSSPPP LQNRKSPSPL AFCPCPPVNS ISKELPFLLH AFYPGYPLLL PPPHLFTYGA LPSDQCPHLL MLPQDPSYPT MAMPSLLMMV NELGHPSARW ETLLPYPGAF QASGQALPSQ ARNPGAGAAP TDSPGLERGG MASPAKRVPL SSQTGTAALP YPLKKKNGKI LYECNICGKS FGQLSNLKVH LRVHSGERPF QCALCQKSFT QLAHLQKHHL VHTGERPHKC SIPWVPGRNH WKSFQAWRER EVCHKRFSSS SNLKTHLRLH SGARPFQCSV CRSRFTQHIH LKLHHRLHAP QPCGLVHTQL PLASLACLAQ WHQGALDLMA VASEKHMGYD IDEVKVSSTS QGKARAVSLS SAGTPLVMGQ DQNN
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