About Zinc finger protein 34
Zinc finger protein 34 (ZNF34) is a protein
from Homo sapiens identified by UniProt accession
Q8IZ26, 560 residues long.
MolForge cross-references it against 0 known binders and
84 disease associations.
Target properties
| Protein name | Zinc finger protein 34 |
|---|
| UniProt accession | Q8IZ26 |
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| Gene | ZNF34 |
|---|
| Organism | Homo sapiens |
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| Length | 560 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (84)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.22
- type 2 diabetes mellitus · score 0.18
- hemoglobin E-beta-thalassemia syndrome · score 0.05
- dehydrated hereditary stomatocytosis · score 0.05
- FTH1-related iron overload · score 0.04
- hemochromatosis type 5 · score 0.04
- primary familial polycythemia due to EPO receptor mutation · score 0.04
- Hemolytic anemia due to red cell pyruvate kinase deficiency · score 0.04
- primary intestinal lymphangiectasia · score 0.04
- hemoglobin D disease · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IZ26-F1 | alphafold | PREDICTED | 69.66 | — |
Amino-acid sequence (560 residues)
MLLLLSDQLL LTALRKPNPQ AMAALFLSAP PQAEVTFEDV AVYLSREEWG RLGPAQRGLY RDVMLETYGN LVSLGVGPAG PKPGVISQLE RGDEPWVLDV QGTSGKEHLR VNSPALGTRT EYKELTSQET FGEEDPQGSE PVEACDHISK SEGSLEKLVE QRGPRAVTLT NGESSRESGG NLRLLSRPVP DQRPHKCDIC EQSFEQRSYL NNHKRVHRSK KTNTVRNSGE IFSANLVVKE DQKIPTGKKL HYCSYCGKTF RYSANLVKHQ RLHTEEKPYK CDECGKAFSQ SCEFINHRRM HSGEIPYRCD ECGKTFTRRP NLMKHQRIHT GEKPYKCGEC GKHFSAYSSL IYHQRIHTGE KPYKCNDCGK AFSDGSILIR HRRTHTGEKP FECKECGKGF TQSSNLIQHQ RIHTGEKPYK CNECEKAFIQ KTKLVEHQRS HTGEKPYECN DCGKVFSQST HLIQHQRIHT GEKPYKCSEC GKAFHNSSRL IHHQRLHHGE KPYRCSDCKK AFSQSTYLIQ HRRIHTGEKP YKCSECGKAF RHSSNMCQHQ RIHLREDFSM
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