REST corepressor 2 (RCOR2)

About REST corepressor 2

REST corepressor 2 (RCOR2) is a protein from Homo sapiens identified by UniProt accession Q8IZ40, 523 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	REST corepressor 2
UniProt accession	Q8IZ40
Gene	RCOR2
Organism	Homo sapiens
Length	523 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.55
lysosomal storage disease · score 0.35
bipolar disorder · score 0.09
schizophrenia · score 0.08
unipolar depression · score 0.07
pulse pressure measurement · score 0.06
hypertriglyceridemia 2 · score 0.06
obsessive-compulsive disorder · score 0.06
attention deficit hyperactivity disorder · score 0.06
autism spectrum disorder · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IZ40-F1	alphafold	PREDICTED	67.30	—

Amino-acid sequence (523 residues)

MPSVMEKPSA GSGILSRSRA KTVPNGGQPH SEDDSSEEEH SHDSMIRVGT NYQAVIPECK PESPARYSNK ELKGMLVWSP NHCVSDAKLD KYIAMAKEKH GYNIEQALGM LLWHKHDVEK SLADLANFTP FPDEWTVEDK VLFEQAFGFH GKCFQRIQQM LPDKLIPSLV KYYYSWKKTR SRTSVMDRQA RRLGGRKDKE DSDELEEGRG GVSEGEPDPA DPKREPLPSR PLNARPGPGK KEVQVSQYRH HPLRTRRRPP KGMYLSPEGL TAVSGSPDLA NLTLRGLDSQ LISLKRQVQS MKQTNSSLRQ ALEGGIDPLR PPEANTKFNS RWTTDEQLLA VQAIRRYGKD FGAIAEVIGN KTLTQVKTFF VSYRRRFNLE EVLQEWEAEQ DGAPGAPVPM EEARRGAPLP APALEEDDEV QITSVSTSVP RSVPPAPPPP PPPTSLSQPP PLLRPPLPTA PTLLRQPPPL QQGRFLQPRL APNQPPPPLI RPALAAPRHS ARPGPQPPPT LIGTPLEPPA PSL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards