About tRNA (uracil-5-)-methyltransferase homolog A
tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A) is a protein
from Homo sapiens identified by UniProt accession
Q8IZ69, 625 residues long.
MolForge cross-references it against 0 known binders and
16 disease associations.
Target properties
| Protein name | tRNA (uracil-5-)-methyltransferase homolog A |
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| UniProt accession | Q8IZ69 |
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| Gene | TRMT2A |
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| Organism | Homo sapiens |
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| Length | 625 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (16)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.16
- blood protein measurement · score 0.10
- cardiovascular disease · score 0.10
- body height · score 0.07
- eosinophil count · score 0.07
- mathematical ability · score 0.05
- transient myeloproliferative syndrome · score 0.05
- smoking status measurement · score 0.05
- triglyceride measurement · score 0.05
- serum metabolite measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IZ69-F1 | alphafold | PREDICTED | 81.58 | — |
Amino-acid sequence (625 residues)
MSENLDNEGP KPMESCGQES SSALSCPTVS VPPAAPAALE EVEKEGAGAA TGPGPQPGLY SYIRDDLFTS EIFKLELQNV PRHASFSDVR RFLGRFGLQP HKTKLFGQPP CAFVTFRSAA ERDKALRVLH GALWKGRPLS VRLARPKADP MARRRRQEGE SEPPVTRVAD VVTPLWTVPY AEQLERKQLE CEQVLQKLAK EIGSTNRALL PWLLEQRHKH NKACCPLEGV RPSPQQTEYR NKCEFLVGVG VDGEDNTVGC RLGKYKGGTC AVAAPFDTVH IPEATKQVVK AFQEFIRSTP YSAYDPETYT GHWKQLTVRT SRRHQAMAIA YFHPQKLSPE ELAELKTSLA QHFTAGPGRA SGVTCLYFVE EGQRKTPSQE GLPLEHVAGD RCIHEDLLGL TFRISPHAFF QVNTPAAEVL YTVIQDWAQL DAGSMVLDVC CGTGTIGLAL ARKVKRVIGV ELCPEAVEDA RVNAQDNELS NVEFHCGRAE DLVPTLVSRL ASQHLVAILD PPRAGLHSKV ILAIRRAKNL RRLLYVSCNP RAAMGNFVDL CRAPSNRVKG IPFRPVKAVA VDLFPQTPHC EMLILFERVE HPNGTGVLGP HSPPAQPTPG PPDNTLQETG TFPSS
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