About Pseudouridylate synthase RPUSD2
Pseudouridylate synthase RPUSD2 (RPUSD2) is a protein
from Homo sapiens identified by UniProt accession
Q8IZ73, 545 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | Pseudouridylate synthase RPUSD2 |
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| UniProt accession | Q8IZ73 |
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| Gene | RPUSD2 |
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| Organism | Homo sapiens |
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| Length | 545 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (34)
Diseases linked to this target (Open Targets).
- insulin like growth factor measurement · score 0.07
- lymphocyte:monocyte ratio · score 0.07
- Red cell distribution width · score 0.06
- Abnormality of refraction · score 0.06
- IGF-1 measurement · score 0.05
- blood protein measurement · score 0.05
- lymphocyte count · score 0.05
- X-linked retinal dysplasia · score 0.05
- severe early-childhood-onset retinal dystrophy · score 0.05
- lymphocyte percentage of leukocytes · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IZ73-F1 | alphafold | PREDICTED | 74.92 | — |
Amino-acid sequence (545 residues)
MWLDRRGWLR VLGHWRYDLR RPSFTRTWSG DKGPMAETVS TQVGTEGGLR ASHQQNGDAG GDAKVELSPG PPKPAGREVE PAPVGGEHPS AAAPGPGKHK KRRGATRERV VPPPKKRRTG VSFGDEHFAE TSYYFEGGLR KVRPYYFDFR TYCKGRWVGH SLLHVFSTEF RAQPLAYYEA AVRAGRLQLN EKPVQDLNIV LKDNDFLRNT VHRHEPPVTA EPIRLLAENE DVVVVDKPSS IPVHPCGRFR HNTVIFILGK EHQLKELHPL HRLDRLTSGV LMFAKTAAVS ERIHEQVRDR QLEKEYVCRV EGEFPTEEVT CKEPILVVSY KVGVCRVDPR GKPCETVFQR LSYNGQSSVV RCRPLTGRTH QIRVHLQFLG HPILNDPIYN SVAWGPSRGR GGYIPKTNEE LLRDLVAEHQ AKQSLDVLDL CEGDLSPGLT DSTAPSSELG KDDLEELAAA AQKMEEVAEA APQELDTIAL ASEKAVETDV MNQETDPLCA ECRLVRQDPL PQDLVMFLHA LRYKGPGFEY FSPMPAWAQD DWQKD
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