About CKLF-like MARVEL transmembrane domain-containing protein 1
CKLF-like MARVEL transmembrane domain-containing protein 1 (CMTM1) is a protein
from Homo sapiens identified by UniProt accession
Q8IZ96, 169 residues long.
MolForge cross-references it against 0 known binders and
30 disease associations.
Target properties
| Protein name | CKLF-like MARVEL transmembrane domain-containing protein 1 |
|---|
| UniProt accession | Q8IZ96 |
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| Gene | CMTM1 |
|---|
| Organism | Homo sapiens |
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| Length | 169 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (30)
Diseases linked to this target (Open Targets).
- genetic disorder · score 0.12
- hepatocellular carcinoma · score 0.08
- Agouti-related protein measurement · score 0.05
- blood protein measurement · score 0.04
- neoplasm · score 0.04
- response to risperidone · score 0.02
- attention deficit hyperactivity disorder · score 0.02
- Tourette syndrome · score 0.02
- obsessive-compulsive disorder · score 0.02
- autism spectrum disorder · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IZ96-F1 | alphafold | PREDICTED | 66.70 | — |
Amino-acid sequence (169 residues)
MDPEHAKPES SEAPSGNLKQ PETAAALSLI LGALACFIIT QANESFITIT SLEICIVVFF ILIYVLTLHH LLTYLHWPLL DLTNSIITAV FLSVVAILAM QEKKRRHLLY VGGSLCLTAV IVCCIDAFVV TTKMRTNLKR FLGVEVERKL SPAKDAYPET GPDAPQRPA
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