About Rhotekin-2
Rhotekin-2 (RTKN2) is a protein
from Homo sapiens identified by UniProt accession
Q8IZC4, 609 residues long.
MolForge cross-references it against 0 known binders and
101 disease associations.
Target properties
| Protein name | Rhotekin-2 |
|---|
| UniProt accession | Q8IZC4 |
|---|
| Gene | RTKN2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 609 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (101)
Diseases linked to this target (Open Targets).
- rheumatoid arthritis · score 0.41
- neurodegenerative disease · score 0.40
- hypothyroidism · score 0.39
- BMI-adjusted waist-hip ratio · score 0.37
- waist-hip ratio · score 0.34
- cardiovascular disease · score 0.33
- triglyceride measurement · score 0.32
- autoimmune thyroid disease · score 0.29
- Thyroid preparation use measurement · score 0.28
- sex hormone-binding globulin measurement · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IZC4-F1 | alphafold | PREDICTED | 69.87 | — |
Amino-acid sequence (609 residues)
MEGPSLRGPA LRLAGLPTQQ DCNIQEKIDL EIRMREGIWK LLSLSTQKDQ VLHAVKNLMV CNARLMAYTS ELQKLEEQIA NQTGRCDVKF ESKERTACKG KIAISDIRIP LMWKDSDHFS NKERSRRYAI FCLFKMGANV FDTDVVNVDK TITDICFENV TIFNEAGPDF QIKVEVYSCC TEESSITNTP KKLAKKLKTS ISKATGKKIS SVLQEEDDEM CLLLSSAVFG VKYNLLAHTT LTLESAEDSF KTHNLSINGN EESSFWLPLY GNMCCRLVAQ PACMAEDAFA GFLNQQQMVE GLISWRRLYC VLRGGKLYCF YSPEEIEAKV EPALVVPINK ETRIRAMDKD AKKRIHNFSV INPVPGQAIT QIFAVDNRED LQKWMEAFWQ HFFDLSQWKH CCEELMKIEI MSPRKPPLFL TKEATSVYHD MSIDSPMKLE SLTDIIQKKI EETNGQFLIG QHEESLPPPW ATLFDGNHQM VIQKKVLYPA SEPLHDEKGK KRQAPLPPSD KLPFSLKSQS NTDQLVKDNW GKTSVSQTSS LDTKLSTLMH HLQKPMAAPR KLLPARRNRL SDGEHTDTKT NFEAKPVPAP RQKSIKDILD PRSWLQAQV
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