Sterile alpha motif domain-containing protein 14…

About Sterile alpha motif domain-containing protein 14

Sterile alpha motif domain-containing protein 14 (SAMD14) is a protein from Homo sapiens identified by UniProt accession Q8IZD0, 417 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	Sterile alpha motif domain-containing protein 14
UniProt accession	Q8IZD0
Gene	SAMD14
Organism	Homo sapiens
Length	417 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

cup-to-disc ratio measurement · score 0.16
platelet component distribution width · score 0.14
cortical surface area measurement · score 0.11
brain volume measurement · score 0.10
neuroimaging measurement · score 0.10
brain measurement · score 0.09
heel bone mineral density · score 0.07
neoplasm · score 0.03
mathematical ability · score 0.03
Central Nervous System Lymphoma · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IZD0-F1	alphafold	PREDICTED	59.90	—

Amino-acid sequence (417 residues)

MASSKLREPV DEVFDLDLAV PETARLDSSL HKARAQLLAK GRRHRPSRSR LRDSASSAED GEGSDGPGGK VTDGCGSPLH RLRSPLHSGP GSPAGGSFCL DPPGLRRSLD EDEPPPSPLT RYRPLHNAAS HEGLAAASCS PPRSAPSSDS SPSFVRRHPR AEPHSEDDSR DASPPEPASP TIGLDKKTRR KFLDLGVTLR RASTGKSRKE KGSNRLSMGS RESVEGSGRS GGSPFLPFSW FTDSGKGSAS SGSTTSPTCS PKHEGFSPKK SASQESTLSD DSTPPSSSPK IPSGPWQEAK CSYPYHTLSQ SSDEFLDEPL PPVHHWTSQQ VGQWLQSLNL EQYAAEFAAR QVDGPQLLQL DGSKLKSLGL SNSHDRALVK RKLKEMAAAA EKERKAQEKA ARQREKLRRR EQEAKKS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Sterile alpha motif domain-containing protein 14 (SAMD14)