About mRNA-decapping enzyme 1B
mRNA-decapping enzyme 1B (DCP1B) is a protein
from Homo sapiens identified by UniProt accession
Q8IZD4, 617 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | mRNA-decapping enzyme 1B |
|---|
| UniProt accession | Q8IZD4 |
|---|
| Gene | DCP1B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 617 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (53)
Diseases linked to this target (Open Targets).
- body mass index · score 0.32
- cystatin C measurement · score 0.26
- waist-hip ratio · score 0.22
- electrocardiography · score 0.14
- body weight · score 0.12
- body fat percentage · score 0.11
- resting heart rate · score 0.11
- schizophrenia · score 0.11
- lean body mass · score 0.10
- body height · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IZD4-F1 | alphafold | PREDICTED | 56.93 | — |
Amino-acid sequence (617 residues)
MAAVAAGGLV GKGRDISLAA LQRHDPYINR IVDVASQVAL YTFGHRANEW EKTDVEGTLF VYTRSASPKH GFTIMNRLSM ENRTEPITKD LDFQLQDPFL LYRNARLSIY GIWFYDKEEC QRIAELMKNL TQYEQLKAHQ GTGAGISPVI LNSGEGKEVD ILRMLIKAKD EYTKCKTCSE PKKITSSSAI YDNPNLIKPI PVKPSENQQQ RIPQPNQTLD PEPQHLSLTA LFGKQDKATC QETVEPPQTL HQQQQQQQQQ QEKLPIRQGV VRSLSYEEPR RHSPPIEKQL CPAIQKLMVR SADLHPLSEL PENRPCENGS THSAGEFFTG PVQPGSPHNI GTSRGVQNAS RTQNLFEKLQ STPGAANKCD PSTPAPASSA ALNRSRAPTS VTPVAPGKGL AQPPQAYFNG SLPPQTVGHQ AHGREQSTLP RQTLPISGSQ TGSSGVISPQ ELLKKLQIVQ QEQQLHASNR PALAAKFPVL AQSSGTGKPL ESWINKTPNT EQQTPLFQVI SPQRIPATAA PSLLMSPMVF AQPTSVPPKE RESGLLPVGG QEPPAAATSL LLPIQSPEPS VITSSPLTKL QLQEALLYLI QNDDNFLNII YEAYLFSMTQ AAMKKTM
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