About Protein-associating with the carboxyl-terminal domain of ezrin
Protein-associating with the carboxyl-terminal domain of ezrin (SCYL3) is a protein
from Homo sapiens identified by UniProt accession
Q8IZE3, 742 residues long.
MolForge cross-references it against 0 known binders and
81 disease associations.
Target properties
| Protein name | Protein-associating with the carboxyl-terminal domain of ezrin |
|---|
| UniProt accession | Q8IZE3 |
|---|
| Gene | SCYL3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 742 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (81)
Diseases linked to this target (Open Targets).
- Alzheimer disease · score 0.26
- multiple sclerosis · score 0.26
- Parkinson disease · score 0.26
- lysosomal storage disease · score 0.26
- neurodegenerative disease · score 0.26
- body height · score 0.11
- leukocyte count · score 0.11
- hepatocellular carcinoma · score 0.07
- neoplasm · score 0.07
- monocyte count · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IZE3-F1 | alphafold | PREDICTED | 69.43 | — |
Amino-acid sequence (742 residues)
MGSENSALKS YTLREPPFTL PSGLAVYPAV LQDGKFASVF VYKRENEDKV NKAAKHLKTL RHPCLLRFLS CTVEADGIHL VTERVQPLEV ALETLSSAEV CAGIYDILLA LIFLHDRGHL THNNVCLSSV FVSEDGHWKL GGMETVCKVS QATPEFLRSI QSIRDPASIP PEEMSPEFTT LPECHGHARD AFSFGTLVES LLTILNEQVS ADVLSSFQQT LHSTLLNPIP KCRPALCTLL SHDFFRNDFL EVVNFLKSLT LKSEEEKTEF FKFLLDRVSC LSEELIASRL VPLLLNQLVF AEPVAVKSFL PYLLGPKKDH AQGETPCLLS PALFQSRVIP VLLQLFEVHE EHVRMVLLSH IEAYVEHFTQ EQLKKVILPQ VLLGLRDTSD SIVAITLHSL AVLVSLLGPE VVVGGERTKI FKRTAPSFTK NTDLSLEDSP MCVVCSHHSQ ISPILENPFS SIFPKCFFSG STPINSKKHI QRDYYNTLLQ TGDPFSQPIK FPINGLSDVK NTSEDSENFP SSSKKSEEWP DWSEPEEPEN QTVNIQIWPR EPCDDVKSQC TTLDVEESSW DDCEPSSLDT KVNPGGGITA TKPVTSGEQK PIPALLSLTE ESMPWKSSLP QKISLVQRGD DADQIEPPKV SSQERPLKVP SELGLGEEFT IQVKKKPVKD PEMDWFADMI PEIKPSAAFL ILPELRTEMV PKKDDVSPVM QFSSKFAAAE ITEGEAEGWE EEGELNWEDN NW
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