About Adhesion G protein-coupled receptor F4
Adhesion G protein-coupled receptor F4 (ADGRF4) is a protein
from Homo sapiens identified by UniProt accession
Q8IZF3, 695 residues long.
MolForge cross-references it against 0 known binders and
54 disease associations.
Target properties
| Protein name | Adhesion G protein-coupled receptor F4 |
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| UniProt accession | Q8IZF3 |
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| Gene | ADGRF4 |
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| Organism | Homo sapiens |
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| Length | 695 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (54)
Diseases linked to this target (Open Targets).
- platelet count · score 0.41
- mean platelet volume · score 0.39
- platelet component distribution width · score 0.32
- BMI-adjusted hip circumference · score 0.09
- neoplasm · score 0.08
- Fuchs endothelial corneal dystrophy · score 0.07
- lung adenocarcinoma · score 0.07
- Lisch epithelial corneal dystrophy · score 0.07
- keratoconus 1 · score 0.06
- corneal endothelial dystrophy · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IZF3-F1 | alphafold | PREDICTED | 78.54 | — |
Amino-acid sequence (695 residues)
MKMKSQATMI CCLVFFLSTE CSHYRSKIHL KAGDKLQSPE GKPKTGRIQE KCEGPCISSS NCSQPCAKDF HGEIGFTCNQ KKWQKSAETC TSLSVEKLFK DSTGASRLSV AAPSIPLHIL DFRAPETIES VAQGIRKNCP FDYACITDMV KSSETTSGNI AFIVELLKNI STDLSDNVTR EKMKSYSEVA NHILDTAAIS NWAFIPNKNA SSDLLQSVNL FARQLHIHNN SENIVNELFI QTKGFHINHN TSEKSLNFSM SMNNTTEDIL GMVQIPRQEL RKLWPNASQA ISIAFPTLGA ILREAHLQNV SLPRQVNGLV LSVVLPERLQ EIILTFEKIN KTRNARAQCV GWHSKKRRWD EKACQMMLDI RNEVKCRCNY TSVVMSFSIL MSSKSMTDKV LDYITCIGLS VSILSLVLCL IIEATVWSRV VVTEISYMRH VCIVNIAVSL LTANVWFIIG SHFNIKAQDY NMCVAVTFFS HFFYLSLFFW MLFKALLIIY GILVIFRRMM KSRMMVIGFA IGYGCPLIIA VTTVAITEPE KGYMRPEACW LNWDNTKALL AFAIPAFVIV AVNLIVVLVV AVNTQRPSIG SSKSQDVVII MRISKNVAIL TPLLGLTWGF GIATLIEGTS LTFHIIFALL NAFQGFFILL FGTIMDHKIR DALRMRMSSL KGKSRAAENA SLGPTNGSKL MNRQG
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