About Adhesion G-protein coupled receptor G5
Adhesion G-protein coupled receptor G5 (ADGRG5) is a protein
from Homo sapiens identified by UniProt accession
Q8IZF4, 528 residues long.
MolForge cross-references it against 0 known binders and
23 disease associations.
Target properties
| Protein name | Adhesion G-protein coupled receptor G5 |
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| UniProt accession | Q8IZF4 |
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| Gene | ADGRG5 |
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| Organism | Homo sapiens |
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| Length | 528 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (23)
Diseases linked to this target (Open Targets).
- mosaic loss of chromosome Y measurement · score 0.34
- mean corpuscular volume · score 0.30
- mean corpuscular hemoglobin · score 0.28
- platelet count · score 0.28
- basophil count · score 0.28
- mean corpuscular hemoglobin concentration · score 0.24
- platelet crit · score 0.22
- mean reticulocyte volume · score 0.21
- erythrocyte count · score 0.20
- metabolite measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IZF4-F1 | alphafold | PREDICTED | 82.40 | — |
Amino-acid sequence (528 residues)
MDHCGALFLC LCLLTLQNAT TETWEELLSY MENMQVSRGR SSVFSSRQLH QLEQMLLNTS FPGYNLTLQT PTIQSLAFKL SCDFSGLSLT SATLKRVPQA GGQHARGQHA MQFPAELTRD ACKTRPRELR LICIYFSNTH FFKDENNSSL LNNYVLGAQL SHGHVNNLRD PVNISFWHNQ SLEGYTLTCV FWKEGARKQP WGGWSPEGCR TEQPSHSQVL CRCNHLTYFA VLMQLSPALV PAELLAPLTY ISLVGCSISI VASLITVLLH FHFRKQSDSL TRIHMNLHAS VLLLNIAFLL SPAFAMSPVP GSACTALAAA LHYALLSCLT WMAIEGFNLY LLLGRVYNIY IRRYVFKLGV LGWGAPALLV LLSLSVKSSV YGPCTIPVFD SWENGTGFQN MSICWVRSPV VHSVLVMGYG GLTSLFNLVV LAWALWTLRR LRERADAPSV RACHDTVTVL GLTVLLGTTW ALAFFSFGVF LLPQLFLFTI LNSLYGFFLF LWFCSQRCRS EAEAKAQIEA FSSSQTTQ
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