Adhesion G-protein coupled receptor G4 (ADGRG4)

Homo sapiens — UniProt Q8IZF6

Gene: ADGRG4Homo sapiensSwissProt reviewed

About Adhesion G-protein coupled receptor G4

Adhesion G-protein coupled receptor G4 (ADGRG4) is a protein from Homo sapiens identified by UniProt accession Q8IZF6, 3080 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.

Target properties

Protein nameAdhesion G-protein coupled receptor G4
UniProt accessionQ8IZF6
GeneADGRG4
OrganismHomo sapiens
Length3080 residues
Molecular weight—
EC numbers—
Target classUNCLASSIFIED
Subcellular location—
Keywords—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tierMEDIUM
Druggability score—
Pocket score—
Max clinical phase—

Disease associations (12)

Diseases linked to this target (Open Targets).

  • Crohn's disease · score 0.04
  • breast carcinoma · score 0.03
  • non-small cell lung carcinoma · score 0.03
  • cancer · score 0.01
  • gastric carcinoma · score 0.01
  • ulcerative colitis · score 0.01
  • melanoma · score 0.01
  • neoplasm · score 0.00
  • breast cancer · score 0.00
  • Miyoshi myopathy · score 0.00

3D Structure (10)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

StructureSourceMethodMean pLDDTResolution (Å)
AF-Q8IZF6-F10alphafoldPREDICTED59.87—
AF-Q8IZF6-F9alphafoldPREDICTED57.26—
AF-Q8IZF6-F8alphafoldPREDICTED50.39—
AF-Q8IZF6-F7alphafoldPREDICTED43.49—
AF-Q8IZF6-F1alphafoldPREDICTED39.92—
AF-Q8IZF6-F6alphafoldPREDICTED35.77—
AF-Q8IZF6-F2alphafoldPREDICTED33.77—
AF-Q8IZF6-F5alphafoldPREDICTED33.52—

Amino-acid sequence (3080 residues)

MKEHIIYQKL YGLILMSSFI FLSDTLSLKG KKLDFFGRGD TYVSLIDTIP ELSRFTACID LVFMDDNSRY WMAFSYITNN ALLGREDIDL GLAGDHQQLI LYRLGKTFSI RHHLASFQWH TICLIWDGVK GKLELFLNKE RILEVTDQPH NLTPHGTLFL GHFLKNESSE VKSMMRSFPG SLYYFQLWDH ILENEEFMKC LDGNIVSWEE DVWLVNKIIP TVDRTLRCFV PENMTIQEKS TTVSQQIDMT TPSQITGVKP QNTAHSSTLL SQSIPIFATD YTTISYSNTT SPPLETMTAQ KILKTLVDET ATFAVDVLST SSAISLPTQS ISIDNTTNSM KKTKSPSSES TKTTKMVEAM ATEIFQPPTP SNFLSTSRFT KNSVVSTTSA IKSQSAVTKT TSLFSTIEST SMSTTPCLKQ KSTNTGALPI STAGQEFIES TAAGTVPWFT VEKTSPASTH VGTASSFPPE PVLISTAAPV DSVFPRNQTA FPLATTDMKI AFTVHSLTLP TRLIETTPAP RTAETELTST NFQDVSLPRV EDAMSTSMSK ETSSKTFSFL TSFSFTGTES VQTVIDAEAT RTALTPEITL ASTVAETMLS STITGRVYTQ NTPTADGHLL TLMSTRSAST SKAPESGPTS TTDEAAHLFS SNETIWTSRP DQALLASMNT TTILTFVPNE NFTSAFHENT TYTEYLSATT NITPLKASPE GKGTTANDAT TARYTTAVSK LTSPWFANFS IVSGTTSITN MPEFKLTTLL LKTIPMSTKP ANELPLTPRE TVVPSVDIIS TLACIQPNFS TEESASETTQ TEINGAIVFG GTTTPVPKSA TTQRLNATVT RKEATSHYLM RKSTIAAVAE VSPFSTMLEV TDESAQRVTA SVTVSSFPDI EKLSTPLDNK TATTEVRESW LLTKLVKTTP RSSYNEMTEM FNFNHTYVAH WTSETSEGIS AGSPTSGSTH IFGEPLGAST TRISETSFST TPTDRTATSL SDGILPPQPT AAHSSATPVP VTHMFSLPVN GSSVVAEETE VTMSEPSTLA RAFSTSVLSD VSNLSSTTMT TALVPPLDQT ASTTIVIVPT HGDLIRTTSE ATVISVRKTS MAVPSLTETP FHSLRLSTPV TAKAETTLFS TSVDTVTPST HTLVCSKPPP DNIPPASSTH VISTTSTPEA TQPISQVEET STYALSFPYT FSGGGVVASL ATGTTETSVV DETTPSHISA NKLTTSVNSH ISSSATYRVH TPVSIQLVTS TSVLSSDKDQ MTISLGKTPR TMEVTEMSPS KNSFISYSRG TPSLEMTDTG FPETTKISSH QTHSPSEIPL GTPSDGNLAS SPTSGSTQIT PTLTSSNTVG VHIPEMSTSL GKTALPSQAL TITTFLCPEK ESTSALPAYT PRTVEMIVNS TYVTHSVSYG QDTSFVDTTT SSSTRISNPM DINTTFSHLH SLRTQPEVTS VASFISESTQ TFPESLSLST AGLYNDGFTV LSDRITTAFS VPNVPTMLPR ESSMATSTPI YQMSSLPVNV TAFTSKKVSD TPPIVITKSS KTMHPGCLKS PCTATSGPMS EMSSIPVNNS AFTPATVSSD TSTRVGLFST LLSSVTPRTT MTMQTSTLDV TPVIYAGATS KNKMVSSAFT TEMIEAPSRI TPTTFLSPTE PTLPFVKTVP TTIMAGIVTP FVGTTAFSPL SSKSTGAISS IPKTTFSPFL SATQQSSQAD EATTLGILSG ITNRSLSTVN SGTGVALTDT YSRITVPENM LSPTHADSLH TSFNIQVSPS LTSFKSASGP TKNVKTTTNC FSSNTRKMTS LLEKTSLTNY ATSLNTPVSY PPWTPSSATL PSLTSFVYSP HSTEAEISTP KTSPPPTSQM VEFPVLGTRM TSSNTQPLLM TSWNIPTAEG SQFPISTTIN VPTSNEMETE TLHLVPGPLS TFTASQTGLV SKDVMAMSSI PMSGILPNHG LSENPSLSTS LRAITSTLAD VKHTFEKMTT SVTPGTTLPS ILSGATSGSV ISKSPILTWL LSSLPSGSPP ATVSNAPHVM TSSTVEVSKS TFLTSDMISA HPFTNLTTLP SATMSTILTR TIPTPTLGGI TTGFPTSLPM SINVTDDIVY ISTHPEASSR TTITANPRTV SHPSSFSRKT MSPSTTDHTL SVGAMPLPSS TITSSWNRIP TASSPSTLII PKPTLDSLLN IMTTTSTVPG ASFPLISTGV TYPFTATVSS PISSFFETTW LDSTPSFLST EASTSPTATK STVSFYNVEM SFSVFVEEPR IPITSVINEF TENSLNSIFQ NSEFSLATLE TQIKSRDISE EEMVMDRAIL EQREGQEMAT ISYVPYSCVC QVIIKASSSL ASSELMRKIK SKIHGNFTHG NFTQDQLTLL VNCEHVAVKK LEPGNCKADE TASKYKGTYK WLLTNPTETA QTRCIKNEDG NATRFCSISI NTGKSQWEKP KFKQCKLLQE LPDKIVDLAN ITISDENAED VAEHILNLIN ESPALGKEET KIIVSKISDI SQCDEISMNL THVMLQIINV VLEKQNNSAS DLHEISNEIL RIIERTGHKM EFSGQIANLT VAGLALAVLR GDHTFDGMAF SIHSYEEGTD PEIFLGNVPV GGILASIYLP KSLTERIPLS NLQTILFNFF GQTSLFKTKN VTKALTTYVV SASISDDMFI QNLADPVVIT LQHIGGNQNY GQVHCAFWDF ENNNGLGGWN SSGCKVKETN VNYTICQCDH LTHFGVLMDL SRSTVDSVNE QILALITYTG CGISSIFLGV AVVTYIAFHK LRKDYPAKIL INLCTALLML NLVFLINSWL SSFQKVGVCI TAAVALHYFL LVSFTWMGLE AVHMYLALVK VFNIYIPNYI LKFCLVGWGI PAIMVAITVS VKKDLYGTLS PTTPFCWIKD DSIFYISVVA YFCLIFLMNL SMFCTVLVQL NSVKSQIQKT RRKMILHDLK GTMSLTFLLG LTWGFAFFAW GPMRNFFLYL FAIFNTLQGF FIFVFHCVMK ESVREQWQIH LCCGWLRLDN SSDGSSRCQI KVGYKQEGLK KIFEHKLLTP SLKSTATSST FKSLGSAQGT PSEISFPNDD FDKDPYCSSP

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Quick facts

UniProtQ8IZF6
GeneADGRG4
OrganismHomo sapiens
Length3080
Binders0
Diseases12
View on UniProt