About Zinc finger protein 654
Zinc finger protein 654 (ZNF654) is a protein
from Homo sapiens identified by UniProt accession
Q8IZM8, 1128 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Target properties
| Protein name | Zinc finger protein 654 |
|---|
| UniProt accession | Q8IZM8 |
|---|
| Gene | ZNF654 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 1128 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (45)
Diseases linked to this target (Open Targets).
- lean body mass · score 0.24
- body weight · score 0.23
- body mass index · score 0.22
- fat body mass · score 0.22
- reticulocyte count · score 0.19
- mean corpuscular volume · score 0.19
- mean corpuscular hemoglobin concentration · score 0.16
- base metabolic rate measurement · score 0.16
- mean reticulocyte volume · score 0.15
- platelet count · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IZM8-F1 | alphafold | PREDICTED | 63.95 | — |
Amino-acid sequence (1128 residues)
MAEEESDQEA ERLGEELVAI VESPLGPVGL RAAGDGRGGA GSGNCGGGVG ISSRDYCRRF CQVVEDYAGR WQVPLPQLQV LQTALCCFTT ASASFPDECE HVQYVLSSLA VSFFELLLFF GRDEFYEEPL KDILGSFQEC QNHLRRYGNV NLELVTRIIR DGGPWEDPVL QAVLKAQPAS QEIVNKYLSS ENPLFFELRA RYLIACERIP EAMALIKSCI NHPEISKDLY FHQALFTCLF MSPVEDQLFR EHLLKTDCKS GIDIICNAEK EGKTMLALQL CESFLIPQLQ NGDMYCIWEL IFIWSKLQLK SNPSKQVFVD QCYQLLRTAT NVRVIFPFMK IIKDEVEEEG LQICVEICGC ALQLDLHDDP KTKCLIYKTI AHFLPNDLEI LRICALSIFF LERSLEAYRT VEELYKRPDE EYNEGTSSVQ NRVRFELLPI LKKGLFFDPE FWNFVMIKKN CVALLSDKSA VRFLNESTLE NNAGNLKRTE EQQGLDEGFD SLTDQSTGET DPDDVSGVQP KGHINTKKNL TALSTSKVDH NVPRHRCMLC NKEFLGGHIV RHAQAHQKKG SFACVICGRK FRNRGLMQKH LKNHVKKIQR QQIAAAQQDD QEVTALEEIN CSSSSISFEN GNSDSKDLEV ETLTASSEGN KEVIPEHVAE FIEIPISVPE DVIENVIENG SPNNSLNNVF KPLTECGDDY EEEEDEEGDY EEDDYDLNQE TSVIHKINGT VCHPKDIYAT DQEGNFKCPA LGCVRIFKRI GFLNKHAMTV HPTDLNVRQT VMKWSKGKCK FCQRQFEDSQ HFIDHLNRHS YPNVYFCLHF NCNESFKLPF QLAQHTKSHR IFQAQCSFPE CHELFEDLPL LYEHEAQHYL SKTPESSAQP SETILWDVQT DSNPNQEKDS SSNEKQTISL PVSTSKSRKE STEPKTCIES MEKKTDSLVQ NGNERSDDTV SNISLIDQKM PDIEPNSENN CSSSDIVNGH SEIEQTPLVS SDPALKIDTN RIRTENGSIL PSVVPQEHNT LPVSQAPSKP NLTSEHTSYG LILTKPYVRP LPPSYLDERY LSMPKRRKFL TDRVDACSDQ DNVYKKSVKR LRCGKCLTTY CNAEALEAHL AQKKCQTLFG FDSDDESA
Explore Zinc finger protein 654 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets