Abl interactor 1 (ABI1)

About Abl interactor 1

Abl interactor 1 (ABI1) is a protein from Homo sapiens identified by UniProt accession Q8IZP0, 508 residues long. MolForge cross-references it against 0 known binders and 170 disease associations.

Target properties

Protein name	Abl interactor 1
UniProt accession	Q8IZP0
Gene	ABI1
Organism	Homo sapiens
Length	508 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (170)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
lobular breast carcinoma · score 0.37
kidney neoplasm · score 0.37
lymphoid neoplasm · score 0.37
breast ductal adenocarcinoma · score 0.37
prostate adenocarcinoma · score 0.37
bile duct carcinoma · score 0.37
esophageal adenocarcinoma · score 0.37
Hepatobiliary Neoplasm · score 0.37
HER2 Positive Breast Carcinoma · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IZP0-F1	alphafold	PREDICTED	65.34	—

Amino-acid sequence (508 residues)

MAELQMLLEE EIPSGKRALI ESYQNLTRVA DYCENNYIQA TDKRKALEET KAYTTQSLAS VAYQINALAN NVLQLLDIQA SQLRRMESSI NHISQTVDIH KEKVARREIG ILTTNKNTSR THKIIAPANM ERPVRYIRKP IDYTVLDDVG HGVKWLKAKH GNNQPARTGT LSRTNPPTQK PPSPPMSGRG TLGRNTPYKT LEPVKPPTVP NDYMTSPARL GSQHSPGRTA SLNQRPRTHS GSSGGSGSRE NSGSSSIGIP IAVPTPSPPT IGPENISVPP PSGAPPAPPL APLLPVSTVI AAPGSAPGSQ YGTMTRQISR HNSTTSSTSS GGYRRTPSVT AQFSAQPHVN GGPLYSQNSI SIAPPPPPMP QLTPQIPLTG FVARVQENIA DSPTPPPPPP PDDIPMFDDS PPPPPPPPVD YEDEEAAVVQ YNDPYADGDP AWAPKNYIEK VVAIYDYTKD KDDELSFMEG AIIYVIKKND DGWYEGVCNR VTGLFPGNYV ESIMHYTD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards