About Heparan-sulfate 6-O-sulfotransferase 3
Heparan-sulfate 6-O-sulfotransferase 3 (HS6ST3) is a protein
from Homo sapiens identified by UniProt accession
Q8IZP7, 471 residues long.
MolForge cross-references it against 0 known binders and
61 disease associations.
Target properties
| Protein name | Heparan-sulfate 6-O-sulfotransferase 3 |
|---|
| UniProt accession | Q8IZP7 |
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| Gene | HS6ST3 |
|---|
| Organism | Homo sapiens |
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| Length | 471 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (61)
Diseases linked to this target (Open Targets).
- body mass index · score 0.50
- lean body mass · score 0.46
- smoking status measurement · score 0.41
- body weight · score 0.39
- fat body mass · score 0.39
- body height · score 0.39
- insomnia measurement · score 0.37
- antisocial behaviour measurement · score 0.37
- attention deficit hyperactivity disorder · score 0.37
- substance abuse · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8IZP7-F1 | alphafold | PREDICTED | 80.39 | — |
Amino-acid sequence (471 residues)
MDERFNKWLL TPVLTLLFVV IMYQYVSPSC TSSCTNFGEQ PRAGEAGPPA VPGPARRAQA PPEEWERRPQ LPPPPRGPPE GPRGAAAPEE EDEEPGDPRE GEEEEEEDEP DPEAPENGSL PRFVPRFNFS LKDLTRFVDF NIKGRDVIVF LHIQKTGGTT FGRHLVKNIR LEQPCSCKAG QKKCTCHRPG KKETWLFSRF STGWSCGLHA DWTELTNCVP AIMEKKDCPR NHSHTRNFYY ITMLRDPVSR YLSEWKHVQR GATWKTSLHM CDGRSPTPDE LPTCYPGDDW SGVSLREFMD CTYNLANNRQ VRMLADLSLV GCYNLTFMNE SERNTILLQS AKNNLKNMAF FGLTEFQRKT QFLFERTFNL KFISPFTQFN ITRASNVEIN EGARQRIEDL NFLDMQLYEY AKDLFQQRYH HTKQLEHQRD RQKRREERRL QREHRDHQWP KEDGAAEGTV TEDYNSQVVR W
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