CKLF-like MARVEL transmembrane domain-containing…

About CKLF-like MARVEL transmembrane domain-containing protein 8

CKLF-like MARVEL transmembrane domain-containing protein 8 (CMTM8) is a protein from Homo sapiens identified by UniProt accession Q8IZV2, 173 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.

Target properties

Protein name	CKLF-like MARVEL transmembrane domain-containing protein 8
UniProt accession	Q8IZV2
Gene	CMTM8
Organism	Homo sapiens
Length	173 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (26)

Diseases linked to this target (Open Targets).

body height · score 0.31
metabolite measurement · score 0.14
urinary bladder carcinoma · score 0.06
eosinophil count · score 0.05
triple-negative breast cancer · score 0.03
gonorrhea · score 0.03
neoplasm · score 0.03
neurofibrillary tangles measurement · score 0.03
Acute hepatic failure · score 0.01
hepatocellular carcinoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8IZV2-F1	alphafold	PREDICTED	77.65	—

Amino-acid sequence (173 residues)

MEEPQRARSH TVTTTASSFA ENFSTSSSSF AYDREFLRTL PGFLIVAEIV LGLLVWTLIA GTEYFRVPAF GWVMFVAVFY WVLTVFFLII YITMTYTRIP QVPWTTVGLC FNGSAFVLYL SAAVVDASSV SPERDSHNFN SWAASSFFAF LVTICYAGNT YFSFIAWRSR TIQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

CKLF-like MARVEL transmembrane domain-containing protein 8 (CMTM8)