Actin-binding Rho-activating protein (ABRA)

About Actin-binding Rho-activating protein

Actin-binding Rho-activating protein (ABRA) is a protein from Homo sapiens identified by UniProt accession Q8N0Z2, 381 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.

Target properties

Protein name	Actin-binding Rho-activating protein
UniProt accession	Q8N0Z2
Gene	ABRA
Organism	Homo sapiens
Length	381 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (29)

Diseases linked to this target (Open Targets).

intraocular pressure measurement · score 0.41
electrocardiography · score 0.25
protein measurement · score 0.21
hip bone size · score 0.20
mean corpuscular volume · score 0.20
hip bone mineral density · score 0.16
reticulocyte count · score 0.15
neutrophil count · score 0.13
glaucoma · score 0.11
neutrophil percentage of leukocytes · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N0Z2-F1	alphafold	PREDICTED	66.45	—

Amino-acid sequence (381 residues)

MAPGEKESGE GPAKSALRKI RTATLVISLA RGWQQWANEN SIRQAQEPTG WLPGGTQDSP QAPKPITPPT SHQKAQSAPK SPPRLPEGHG DGQSSEKAPE VSHIKKKEVS KTVVSKTYER GGDVSHLSHR YERDAGVLEP GQPENDIDRI LHSHGSPTRR RKCANLVSEL TKGWRVMEQE EPTWRSDSVD TEDSGYGGEA EERPEQDGVQ VAVVRIKRPL PSQVNRFTEK LNCKAQQKYS PVGNLKGRWQ QWADEHIQSQ KLNPFSEEFD YELAMSTRLH KGDEGYGRPK EGTKTAERAK RAEEHIYREM MDMCFIICTM ARHRRDGKIQ VTFGDLFDRY VRISDKVVGI LMRARKHGLV DFEGEMLWQG RDDHVVITLL K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards