About Transcription factor ATOH7
Transcription factor ATOH7 (ATOH7) is a protein
from Homo sapiens identified by UniProt accession
Q8N100, 152 residues long.
MolForge cross-references it against 0 known binders and
174 disease associations.
Target properties
| Protein name | Transcription factor ATOH7 |
|---|
| UniProt accession | Q8N100 |
|---|
| Gene | ATOH7 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 152 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (174)
Diseases linked to this target (Open Targets).
- persistent hyperplastic primary vitreous, autosomal recessive · score 0.71
- neurodegenerative disease · score 0.45
- Autosomal dominant optic atrophy, classic type · score 0.43
- foveal hypoplasia · score 0.42
- Hypoplasia of the fovea · score 0.42
- cup-to-disc ratio measurement · score 0.38
- optic disc size measurement · score 0.37
- persistent hyperplastic primary vitreous · score 0.37
- Congenital cataract microcornea with corneal opacity · score 0.37
- optic cup area measurement · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N100-F1 | alphafold | PREDICTED | 71.72 | — |
Amino-acid sequence (152 residues)
MKSCKPSGPP AGARVAPPCA GGTECAGTCA GAGRLESAAR RRLAANARER RRMQGLNTAF DRLRRVVPQW GQDKKLSKYE TLQMALSYIM ALTRILAEAE RFGSERDWVG LHCEHFGRDH YLPFPGAKLP GESELYSQRL FGFQPEPFQM AT
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