About T-cell activation Rho GTPase-activating protein
T-cell activation Rho GTPase-activating protein (TAGAP) is a protein
from Homo sapiens identified by UniProt accession
Q8N103, 731 residues long.
MolForge cross-references it against 0 known binders and
95 disease associations.
Target properties
| Protein name | T-cell activation Rho GTPase-activating protein |
|---|
| UniProt accession | Q8N103 |
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| Gene | TAGAP |
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| Organism | Homo sapiens |
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| Length | 731 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (95)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.49
- celiac disease · score 0.48
- leukocyte count · score 0.48
- myeloid white cell count · score 0.45
- lymphocyte count · score 0.44
- multiple sclerosis · score 0.44
- Crohn's disease · score 0.43
- rheumatoid arthritis · score 0.41
- psoriasis · score 0.38
- type 1 diabetes mellitus · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N103-F1 | alphafold | PREDICTED | 56.96 | — |
Amino-acid sequence (731 residues)
MKLRSSHNAS KTLNANNMET LIECQSEGDI KEHPLLASCE SEDSICQLIE VKKRKKVLSW PFLMRRLSPA SDFSGALETD LKASLFDQPL SIICGDSDTL PRPIQDILTI LCLKGPSTEG IFRRAANEKA RKELKEELNS GDAVDLERLP VHLLAVVFKD FLRSIPRKLL SSDLFEEWMG ALEMQDEEDR IEALKQVADK LPRPNLLLLK HLVYVLHLIS KNSEVNRMDS SNLAICIGPN MLTLENDQSL SFEAQKDLNN KVKTLVEFLI DNCFEIFGEN IPVHSSITSD DSLEHTDSSD VSTLQNDSAY DSNDPDVESN SSSGISSPSR QPQVPMATAA GLDSAGPQDA REVSPEPIVS TVARLKSSLA QPDRRYSEPS MPSSQECLES RVTNQTLTKS EGDFPVPRVG SRLESEEAED PFPEEVFPAV QGKTKRPVDL KIKNLAPGSV LPRALVLKAF SSSSLDASSD SSPVASPSSP KRNFFSRHQS FTTKTEKGKP SREIKKHSMS FTFAPHKKVL TKNLSAGSGK SQDFTRDHVP RGVRKESQLA GRIVQENGCE THNQTARGFC LRPHALSVDD VFQGADWERP GSPPSYEEAM QGPAARLVAS ESQTVGSMTV GSMRARMLEA HCLLPPLPPA HHVEDSRHRG SKEPLPGHGL SPLPERWKQS RTVHASGDSL GHVSGPGRPE LLPLRTVSES VQRNKRDCLV RRCSQPVFEA DQFQYAKESY I
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