Leucine-rich single-pass membrane protein 2 (LSMEM2)

About Leucine-rich single-pass membrane protein 2

Leucine-rich single-pass membrane protein 2 (LSMEM2) is a protein from Homo sapiens identified by UniProt accession Q8N112, 164 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.

Target properties

Protein name	Leucine-rich single-pass membrane protein 2
UniProt accession	Q8N112
Gene	LSMEM2
Organism	Homo sapiens
Length	164 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (24)

Diseases linked to this target (Open Targets).

reticulocyte count · score 0.30
blood protein measurement · score 0.19
schizophrenia · score 0.14
neuroticism measurement · score 0.12
wellbeing measurement · score 0.11
mean platelet volume · score 0.10
depressive symptom measurement · score 0.08
neurotic disorder · score 0.08
chronotype measurement · score 0.07
tea consumption measurement · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N112-F1	alphafold	PREDICTED	66.60	—

Amino-acid sequence (164 residues)

MPSLAPDCPL LAMPEETQED SVAPMMPSQR SRGPLAPNHV HEVCLHQVES ISDLHSGAGT LRPYLTEEAR PWDELLGVLP PSLCAQAGCS PVYRRGGFLL LLALLVLTCL VLALLAVYLS VLQSESLRIL AHTLRTQEET LLKLRLASLS QLRRLNSSEA QAPS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards