About Protein shisa-5
Protein shisa-5 (SHISA5) is a protein
from Homo sapiens identified by UniProt accession
Q8N114, 240 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | Protein shisa-5 |
|---|
| UniProt accession | Q8N114 |
|---|
| Gene | SHISA5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 240 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (28)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.30
- Aicardi-Goutieres syndrome 1 · score 0.27
- BMI-adjusted waist-hip ratio · score 0.12
- psoriasis · score 0.11
- BMI-adjusted waist circumference · score 0.08
- eosinophil count · score 0.06
- HbA1c measurement · score 0.04
- bilirubin measurement · score 0.04
- alkaline phosphatase measurement · score 0.04
- glomerular filtration rate · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N114-F1 | alphafold | PREDICTED | 58.68 | — |
Amino-acid sequence (240 residues)
MTAPVPAPRI LLPLLLLLLL TPPPGARGEV CMASRGLSLF PESCPDFCCG TCDDQYCCSD VLKKFVWSEE RCAVPEASVP ASVEPVEQLG SALRFRPGYN DPMSGFGATL AVGLTIFVLS VVTIIICFTC SCCCLYKTCR RPRPVVTTTT STTVVHAPYP QPPSVPPSYP GPSYQGYHTM PPQPGMPAAP YPMQYPPPYP AQPMGPPAYH ETLAGGAAAP YPASQPPYNP AYMDAPKAAL
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