About Matrix metalloproteinase-21
Matrix metalloproteinase-21 (MMP21) is a protein
from Homo sapiens identified by UniProt accession
Q8N119, 569 residues long.
MolForge cross-references it against 0 known binders and
75 disease associations.
Target properties
| Protein name | Matrix metalloproteinase-21 |
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| UniProt accession | Q8N119 |
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| Gene | MMP21 |
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| Organism | Homo sapiens |
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| Length | 569 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (75)
Diseases linked to this target (Open Targets).
- visceral heterotaxy · score 0.71
- Heterotaxia · score 0.68
- Situs inversus totalis · score 0.37
- genetic disorder · score 0.19
- appendicular lean mass · score 0.10
- Red cell distribution width · score 0.06
- congenital heart disease · score 0.06
- heterotaxy, visceral, 12, autosomal · score 0.06
- ventricular septal defect 1 · score 0.06
- fallot complex-intellectual disability-growth delay syndrome · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N119-F1 | alphafold | PREDICTED | 83.81 | — |
Amino-acid sequence (569 residues)
MLAASIFRPT LLLCWLAAPW PTQPESLFHS RDRSDLEPSP LRQAKPIADL HAAQRFLSRY GWSGVWAAWG PSPEGPPETP KGAALAEAVR RFQRANALPA SGELDAATLA AMNRPRCGVP DMRPPPPSAP PSPPGPPPRA RSRRSPRAPL SLSRRGWQPR GYPDGGAAQA FSKRTLSWRL LGEALSSQLS VADQRRIVAL AFRMWSEVTP LDFREDLAAP GAAVDIKLGF GRGRHLGCPR AFDGSGQEFA HAWRLGDIHF DDDEHFTPPT SDTGISLLKV AVHEIGHVLG LPHTYRTGSI MQPNYIPQEP AFELDWSDRK AIQKLYGSCE GSFDTAFDWI RKERNQYGEV MVRFSTYFFR NSWYWLYENR NNRTRYGDPI QILTGWPGIP THNIDAFVHI WTWKRDERYF FQGNQYWRYD SDKDQALTED EQGKSYPKLI SEGFPGIPSP LDTAFYDRRQ KLIYFFKESL VFAFDVNRNR VLNSYPKRIT EVFPAVIPQN HPFRNIDSAY YSYAYNSIFF FKGNAYWKVV NDKDKQQNSW LPANGLFPKK FISEKWFDVC DVHISTLNM
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