Cell adhesion molecule 3 (CADM3)

About Cell adhesion molecule 3

Cell adhesion molecule 3 (CADM3) is a protein from Homo sapiens identified by UniProt accession Q8N126, 398 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.

Target properties

Protein name	Cell adhesion molecule 3
UniProt accession	Q8N126
Gene	CADM3
Organism	Homo sapiens
Length	398 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (64)

Diseases linked to this target (Open Targets).

Charcot-Marie-Tooth disease, axonal, type 2FF · score 0.47
neurodegenerative disease · score 0.46
self reported educational attainment · score 0.31
mathematical ability · score 0.30
asthma · score 0.27
breast adenocarcinoma · score 0.26
genetic disorder · score 0.19
head and neck squamous cell carcinoma · score 0.19
CCL2 measurement · score 0.16
intelligence · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N126-F1	alphafold	PREDICTED	84.38	—

Amino-acid sequence (398 residues)

MGAPAASLLL LLLLFACCWA PGGANLSQDD SQPWTSDETV VAGGTVVLKC QVKDHEDSSL QWSNPAQQTL YFGEKRALRD NRIQLVTSTP HELSISISNV ALADEGEYTC SIFTMPVRTA KSLVTVLGIP QKPIITGYKS SLREKDTATL NCQSSGSKPA ARLTWRKGDQ ELHGEPTRIQ EDPNGKTFTV SSSVTFQVTR EDDGASIVCS VNHESLKGAD RSTSQRIEVL YTPTAMIRPD PPHPREGQKL LLHCEGRGNP VPQQYLWEKE GSVPPLKMTQ ESALIFPFLN KSDSGTYGCT ATSNMGSYKA YYTLNVNDPS PVPSSSSTYH AIIGGIVAFI VFLLLIMLIF LGHYLIRHKG TYLTHEAKGS DDAPDADTAI INAEGGQSGG DDKKEYFI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards