Protein canopy homolog 4 (CNPY4)

About Protein canopy homolog 4

Protein canopy homolog 4 (CNPY4) is a protein from Homo sapiens identified by UniProt accession Q8N129, 248 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.

Target properties

Protein name	Protein canopy homolog 4
UniProt accession	Q8N129
Gene	CNPY4
Organism	Homo sapiens
Length	248 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (85)

Diseases linked to this target (Open Targets).

genetic disorder · score 0.15
azoospermia · score 0.09
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
Female infertility due to fertilization defect · score 0.07
Rare genetic female infertility · score 0.07
partial chromosome Y deletion · score 0.07
male infertility with teratozoospermia due to single gene mutation · score 0.07
spermatogenic failure 3 · score 0.06
spermatogenic failure 55 · score 0.06
spermatogenic failure 26 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N129-F1	alphafold	PREDICTED	79.75	—

Amino-acid sequence (248 residues)

MGPVRLGILL FLFLAVHEAW AGMLKEEDDD TERLPSKCEV CKLLSTELQA ELSRTGRSRE VLELGQVLDT GKRKRHVPYS VSETRLEEAL ENLCERILDY SVHAERKGSL RYAKGQSQTM ATLKGLVQKG VKVDLGIPLE LWDEPSVEVT YLKKQCETML EEFEDIVGDW YFHHQEQPLQ NFLCEGHVLP AAETACLQET WTGKEITDGE EKTEGEEEQE EEEEEEEEEG GDKMTKTGSH PKLDREDL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards