About Leucine-rich repeat LGI family member 4
Leucine-rich repeat LGI family member 4 (LGI4) is a protein
from Homo sapiens identified by UniProt accession
Q8N135, 537 residues long.
MolForge cross-references it against 0 known binders and
152 disease associations.
Target properties
| Protein name | Leucine-rich repeat LGI family member 4 |
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| UniProt accession | Q8N135 |
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| Gene | LGI4 |
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| Organism | Homo sapiens |
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| Length | 537 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (152)
Diseases linked to this target (Open Targets).
- Neurogenic arthrogryposis multiplex congenita · score 0.70
- Hypomyelination neuropathy - arthrogryposis · score 0.62
- arthrogryposis multiplex congenita · score 0.59
- hypomyelination neuropathy-arthrogryposis syndrome · score 0.37
- arthrogryposis multiplex congenita 2, neurogenic type · score 0.34
- genetic disorder · score 0.34
- fetal akinesia deformation sequence · score 0.33
- fetal akinesia deformation sequence 1 · score 0.33
- hematocrit · score 0.14
- hemoglobin measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N135-F1 | alphafold | PREDICTED | 92.32 | — |
Amino-acid sequence (537 residues)
MGGAGILLLL LAGAGVVVAW RPPKGKCPLR CSCSKDSALC EGSPDLPVSF SPTLLSLSLV RTGVTQLKAG SFLRIPSLHL LLFTSNSFSV IEDDAFAGLS HLQYLFIEDN EIGSISKNAL RGLRSLTHLS LANNHLETLP RFLFRGLDTL THVDLRGNPF QCDCRVLWLL QWMPTVNASV GTGACAGPAS LSHMQLHHLD PKTFKCRAIE LSWFQTVGES ALSVEPFSYQ GEPHIVLAQP FAGRCLILSW DYSLQRFRPE EELPAASVVS CKPLVLGPSL FVLAARLWGG SQLWARPSPG LRLAPTQTLA PRRLLRPNDA ELLWLEGQPC FVVADASKAG STTLLCRDGP GFYPHQSLHA WHRDTDAEAL ELDGRPHLLL ASASQRPVLF HWTGGRFERR TDIPEAEDVY ATRHFQAGGD VFLCLTRYIG DSMVMRWDGS MFRLLQQLPS RGAHVFQPLL IARDQLAILG SDFAFSQVLR LEPDKGLLEP LQELGPPALV APRAFAHITM AGRRFLFAAC FKGPTQIYQH HEIDLSA
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