Dynein assembly factor with WD repeat domains 1 (DAW1)

About Dynein assembly factor with WD repeat domains 1

Dynein assembly factor with WD repeat domains 1 (DAW1) is a protein from Homo sapiens identified by UniProt accession Q8N136, 415 residues long. MolForge cross-references it against 0 known binders and 75 disease associations.

Target properties

Protein name	Dynein assembly factor with WD repeat domains 1
UniProt accession	Q8N136
Gene	DAW1
Organism	Homo sapiens
Length	415 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (75)

Diseases linked to this target (Open Targets).

primary ciliary dyskinesia · score 0.50
asthma · score 0.38
allergic rhinitis · score 0.36
Eczematoid dermatitis · score 0.36
adolescent idiopathic scoliosis · score 0.26
seasonal allergic rhinitis · score 0.25
neurodegenerative disease · score 0.20
ciliopathy · score 0.19
allergic disease · score 0.12
Heterotaxia · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N136-F1	alphafold	PREDICTED	96.62	—

Amino-acid sequence (415 residues)

MKLKSLLLRY YPPGIMLEYE KHGELKTKSI DLLDLGPSTD VSALVEEIQK AEPLLTASRT EQVKLLIQRL QEKLGQNSNH TFYLFKVLKA HILPLTNVAL NKSGSCFITG SYDRTCKLWD TASGEELNTL EGHRNVVYAI AFNNPYGDKI ATGSFDKTCK LWSVETGKCY HTFRGHTAEI VCLSFNPQST LVATGSMDTT AKLWDIQNGE EVYTLRGHSA EIISLSFNTS GDRIITGSFD HTVVVWDADT GRKVNILIGH CAEISSASFN WDCSLILTGS MDKTCKLWDA TNGKCVATLT GHDDEILDSC FDYTGKLIAT ASADGTARIF SAATRKCIAK LEGHEGEISK ISFNPQGNHL LTGSSDKTAR IWDAQTGQCL QVLEGHTDEI FSCAFNYKGN IVITGSKDNT CRIWR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards