About Centrobin
Centrobin (CNTROB) is a protein
from Homo sapiens identified by UniProt accession
Q8N137, 903 residues long.
MolForge cross-references it against 0 known binders and
78 disease associations.
Target properties
| Protein name | Centrobin |
|---|
| UniProt accession | Q8N137 |
|---|
| Gene | CNTROB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 903 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (78)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- macula measurement · score 0.10
- azoospermia · score 0.09
- smoking status measurement · score 0.08
- refractive error · score 0.08
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
- Female infertility due to fertilization defect · score 0.07
- Rare genetic female infertility · score 0.07
- partial chromosome Y deletion · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N137-F1 | alphafold | PREDICTED | 66.01 | — |
Amino-acid sequence (903 residues)
MATSADSPSS PLGAEDLLSD SSEPPGLNQV SSEVTSQLYA SLRLSRQAEA TARAQLYLPS TSPPHEGLDG FAQELSRSLS VGLEKNLKKK DGSKHIFEME SVRGQLQTML QTSRDTAYRD PLIPGAGSER REEDSFDSDS TATLLNTRPL QDLSPSSSAQ ALEELFPRYT SLRPGPPLNP PDFQGLRDAL DSEHTRRKHC ERHIQSLQTR VLELQQQLAV AVAADRKKDT MIEQLDKTLA RVVEGWNRHE AERTEVLRGL QEEHQAAELT RSKQQETVTR LEQSLSEAME ALNREQESAR LQQRERETLE EERQALTLRL EAEQQRCCVL QEERDAARAG QLSEHRELET LRAALEEERQ TWAQQEHQLK EHYQALQEES QAQLEREKEK SQREAQAAWE TQHQLALVQS EVRRLEGELD TARRERDALQ LEMSLVQARY ESQRIQLESE LAVQLEQRVT ERLAQAQESS LRQAASLREH HRKQLQDLSG QHQQELASQL AQFKVEMAER EERQQQVAED YELRLAREQA RVCELQSGNQ QLEEQRVELV ERLQAMLQAH WDEANQLLST TLPPPNPPAP PAGPSSPGPQ EPEKEERRVW TMPPMAVALK PVLQQSREAR DELPGAPPVL CSSSSDLSLL LGPSFQSQHS FQPLEPKPDL TSSTAGAFSA LGAFHPDHRA ERPFPEEDPG PDGEGLLKQG LPPAQLEGLK NFLHQLLETV PQNNENPSVD LLPPKSGPLT VPSWEEAPQV PRIPPPVHKT KVPLAMASSL FRVPEPPSSH SQGSGPSSGS PERGGDGLTF PRQLMEVSQL LRLYQARGWG ALPAEDLLLY LKRLEHSGTD GRGDNVPRRN TDSRLGEIPR KEIPSQAVPR RLATAPKTEK PPARKKSGHP APSSMRSRGG VWR
Explore Centrobin with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets