ORM1-like protein 3 (ORMDL3)

About ORM1-like protein 3

ORM1-like protein 3 (ORMDL3) is a protein from Homo sapiens identified by UniProt accession Q8N138, 153 residues long. MolForge cross-references it against 0 known binders and 151 disease associations.

Target properties

Protein name	ORM1-like protein 3
UniProt accession	Q8N138
Gene	ORMDL3
Organism	Homo sapiens
Length	153 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (151)

Diseases linked to this target (Open Targets).

Red cell distribution width · score 0.42
neutrophil count · score 0.14
asthma · score 0.13
leukocyte count · score 0.13
allergic disease · score 0.12
type 1 diabetes mellitus · score 0.11
childhood onset asthma · score 0.10
ulcerative colitis · score 0.10
total blood protein measurement · score 0.10
Chronic Obstructive Asthma · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N138-F1	alphafold	PREDICTED	94.00	—

Amino-acid sequence (153 residues)

MNVGTAHSEV NPNTRVMNSR GIWLSYVLAI GLLHIVLLSI PFVSVPVVWT LTNLIHNMGM YIFLHTVKGT PFETPDQGKA RLLTHWEQMD YGVQFTASRK FLTITPIVLY FLTSFYTKYD QIHFVLNTVS LMSVLIPKLP QLHGVRIFGI NKY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards