B-cell CLL/lymphoma 6 member B protein (BCL6B)

About B-cell CLL/lymphoma 6 member B protein

B-cell CLL/lymphoma 6 member B protein (BCL6B) is a protein from Homo sapiens identified by UniProt accession Q8N143, 479 residues long. MolForge cross-references it against 0 known binders and 139 disease associations.

Target properties

Protein name	B-cell CLL/lymphoma 6 member B protein
UniProt accession	Q8N143
Gene	BCL6B
Organism	Homo sapiens
Length	479 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (139)

Diseases linked to this target (Open Targets).

hepatocellular carcinoma · score 0.10
gonorrhea · score 0.08
neoplasm · score 0.08
colorectal carcinoma · score 0.07
lymphocyte percentage of leukocytes · score 0.07
Blackfan-Diamond anemia · score 0.07
Okt4 epitope deficiency · score 0.07
neutrophil percentage of leukocytes · score 0.07
common variable immunodeficiency · score 0.06
Chronic mucocutaneous candidosis · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N143-F1	alphafold	PREDICTED	54.33	—

Amino-acid sequence (479 residues)

MGSPAAPEGA LGYVREFTRH SSDVLGNLNE LRLRGILTDV TLLVGGQPLR AHKAVLIACS GFFYSIFRGR AGVGVDVLSL PGGPEARGFA PLLDFMYTSR LRLSPATAPA VLAAATYLQM EHVVQACHRF IQASYEPLGI SLRPLEAEPP TPPTAPPPGS PRRSEGHPDP PTESRSCSQG PPSPASPDPK ACNWKKYKYI VLNSQASQAG SLVGERSSGQ PCPQARLPSG DEASSSSSSS SSSSEEGPIP GPQSRLSPTA ATVQFKCGAP ASTPYLLTSQ AQDTSGSPSE RARPLPGSEF FSCQNCEAVA GCSSGLDSLV PGDEDKPYKC QLCRSSFRYK GNLASHRTVH TGEKPYHCSI CGARFNRPAN LKTHSRIHSG EKPYKCETCG SRFVQVAHLR AHVLIHTGEK PYPCPTCGTR FRHLQTLKSH VRIHTGEKPY HCDPCGLHFR HKSQLRLHLR QKHGAATNTK VHYHILGGP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards