Gap junction delta-3 protein (GJD3)

About Gap junction delta-3 protein

Gap junction delta-3 protein (GJD3) is a protein from Homo sapiens identified by UniProt accession Q8N144, 294 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.

Target properties

Protein name	Gap junction delta-3 protein
UniProt accession	Q8N144
Gene	GJD3
Organism	Homo sapiens
Length	294 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (93)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.24
urate measurement · score 0.20
serum gamma-glutamyl transferase measurement · score 0.16
lymphocyte percentage of leukocytes · score 0.13
sex hormone-binding globulin measurement · score 0.12
Varicose veins · score 0.12
platelet component distribution width · score 0.11
familial atrial fibrillation · score 0.10
Romano-Ward syndrome · score 0.09
Familial progressive cardiac conduction defect · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N144-F1	alphafold	PREDICTED	77.26	—

Amino-acid sequence (294 residues)

MGEWAFLGSL LDAVQLQSPL VGRLWLVVML IFRILVLATV GGAVFEDEQE EFVCNTLQPG CRQTCYDRAF PVSHYRFWLF HILLLSAPPV LFVVYSMHRA GKEAGGAEAA AQCAPGLPEA QCAPCALRAR RARRCYLLSV ALRLLAELTF LGGQALLYGF RVAPHFACAG PPCPHTVDCF VSRPTEKTVF VLFYFAVGLL SALLSVAELG HLLWKGRPRA GERDNRCNRA HEEAQKLLPP PPPPPPPPAL PSRRPGPEPC APPAYAHPAP ASLRECGSGR GKASPATGRR DLAI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards