About Leucine-rich repeat LGI family member 3
Leucine-rich repeat LGI family member 3 (LGI3) is a protein
from Homo sapiens identified by UniProt accession
Q8N145, 548 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | Leucine-rich repeat LGI family member 3 |
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| UniProt accession | Q8N145 |
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| Gene | LGI3 |
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| Organism | Homo sapiens |
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| Length | 548 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (47)
Diseases linked to this target (Open Targets).
- intellectual developmental disorder with muscle tone abnormalities and distal skeletal defects · score 0.61
- neurodegenerative disease · score 0.24
- non-small cell lung carcinoma · score 0.08
- Vitiligo · score 0.07
- kidney disease · score 0.04
- hepatorenocardiac degenerative fibrosis · score 0.04
- Senior-Boichis syndrome · score 0.04
- esophageal adenocarcinoma · score 0.03
- Barrett's esophagus · score 0.03
- renal dysplasia · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N145-F1 | alphafold | PREDICTED | 91.52 | — |
Amino-acid sequence (548 residues)
MAGLRARGGP GPGLLALSAL GFCLMLQVSA KRPPKTPPCP PSCSCTRDTA FCVDSKAVPR NLPSEVISLT LVNAAFSEIQ DGAFSHLPLL QFLLLNSNKF TLIGDNAFTG LSHLQYLFIE NNDIWALSKF TFRGLKSLTH LSLANNNLQT LPRDIFRPLD ILNDLDLRGN SLNCDCKVKW LVEWLAHTNT TVAPIYCASP PRFQEHKVQD LPLREFDCIT TDFVLYQTLA FPAVSAEPFL YSSDLYLALA QPGVSACTIL KWDYVERQLR DYDRIPAPSA VHCKPMVVDS QLYVVVAQLF GGSYIYHWDP NTTRFTRLQD IDPQRVRKPN DLEAFRIDGD WYFAVADSSK AGATSLYRWH QNGFYSHQAL HPWHRDTDLE FVDGEGKPRL IVSSSSQAPV IYQWSRTQKQ FVAQGEVTQV PDAQAVKHFR AGRDSYLCLS RYIGDSKILR WEGTRFSEVQ ALPSRGSLAL QPFLVGGRRY LALGSDFSFT QIYQWDEGRQ KFVRFQELAV QAPRAFCYMP AGDAQLLLAP SFKGQTLVYR HIVVDLSA
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