Olfactory receptor 8H3 (OR8H3)

About Olfactory receptor 8H3

Olfactory receptor 8H3 (OR8H3) is a protein from Homo sapiens identified by UniProt accession Q8N146, 312 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.

Target properties

Protein name	Olfactory receptor 8H3
UniProt accession	Q8N146
Gene	OR8H3
Organism	Homo sapiens
Length	312 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (14)

Diseases linked to this target (Open Targets).

neuroblastoma · score 0.21
ovarian cancer · score 0.18
multiple myeloma · score 0.16
apolipoprotein A 1 measurement · score 0.15
myeloid white cell count · score 0.09
cystatin C measurement · score 0.09
Agents acting on the renin-angiotensin system use measurement · score 0.08
IGF-1 measurement · score 0.08
reticulocyte measurement · score 0.06
high density lipoprotein cholesterol measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N146-F1	alphafold	PREDICTED	88.24	—

Amino-acid sequence (312 residues)

MMGRRNDTNV ADFILTGLSD SEEVQMALFM LFLLIYLITM LGNVGMLLII RLDLQLHTPM YFFLTHLSFI DLSYSTVVTP KTLANLLTSN YISFTGCFAQ MFCFVFLGTA ECYLLSSMAY DRYAAICSPL HYTVIMPKRL CLALITGPYV IGFMDSFVNV VSMSRLHFCD SNIIHHFFCD TSPILALSCT DTDNTEMLIF IIAGSTLMVS LITISASYVS ILSTILKINS TSGKQKAFST CVSHLLGVTI FYGTMIFTYL KPRKSYSLGR DQVAPVFYTI VIPMLNPLIY SLRNREVKNA LIRVMQRRQD SR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards