About Homeobox protein SIX5
Homeobox protein SIX5 (SIX5) is a protein
from Homo sapiens identified by UniProt accession
Q8N196, 739 residues long.
MolForge cross-references it against 0 known binders and
282 disease associations.
Target properties
| Protein name | Homeobox protein SIX5 |
|---|
| UniProt accession | Q8N196 |
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| Gene | SIX5 |
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| Organism | Homo sapiens |
|---|
| Length | 739 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (282)
Diseases linked to this target (Open Targets).
- BOR syndrome · score 0.78
- neurodegenerative disease · score 0.48
- serum albumin measurement · score 0.19
- early-onset non-syndromic cataract · score 0.12
- hereditary hyperferritinemia with congenital cataracts · score 0.11
- isolated ectopia lentis · score 0.10
- cataract 13 with adult I phenotype · score 0.10
- cataract 38 · score 0.10
- platelet count · score 0.10
- azoospermia · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N196-F1 | alphafold | PREDICTED | 51.28 | — |
Amino-acid sequence (739 residues)
MATLPAEPSA GPAAGGEAVA AAAATEEEEE EARQLLQTLQ AAEGEAAAAA GAGAGAAAAG AEGPGSPGVP GSPPEAASEP PTGLRFSPEQ VACVCEALLQ AGHAGRLSRF LGALPPAERL RGSDPVLRAR ALVAFQRGEY AELYRLLESR PFPAAHHAFL QDLYLRARYH EAERARGRAL GAVDKYRLRK KFPLPKTIWD GEETVYCFKE RSRAALKACY RGNRYPTPDE KRRLATLTGL SLTQVSNWFK NRRQRDRTGA GGGAPCKSES DGNPTTEDES SRSPEDLERG AAPVSAEAAA QGSIFLAGTG PPAPCPASSS ILVNGSFLAA SGSPAVLLNG GPVIINGLAL GEASSLGPLL LTGGGGAPPP QPSPQGASET KTSLVLDPQT GEVRLEEAQS EAPETKGAQV AAPGPALGEE VLGPLAQVVP GPPTAATFPL PPGPVPAVAA PQVVPLSPPP GYPTGLSPTS PLLNLPQVVP TSQVVTLPQA VGPLQLLAAG PGSPVKVAAA AGPANVHLIN SGVGVTALQL PSATAPGNFL LANPVSGSPI VTGVALQQGK IILTATFPTS MLVSQVLPPA PGLALPLKPE TAISVPEGGL PVAPSPALPE AHALGTLSAQ QPPPAAATTS STSLPFSPDS PGLLPNFPAP PPEGLMLSPA AVPVWSAGLE LSAGTEGLLE AEKGLGTQAP HTVLRLPDPD PEGLLLGATA GGEVDEGLEA EAKVLTQLQS VPVEEPLEL
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