Integrator complex subunit 1 (INTS1)

About Integrator complex subunit 1

Integrator complex subunit 1 (INTS1) is a protein from Homo sapiens identified by UniProt accession Q8N201, 2190 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.

Target properties

Protein name	Integrator complex subunit 1
UniProt accession	Q8N201
Gene	INTS1
Organism	Homo sapiens
Length	2190 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (39)

Diseases linked to this target (Open Targets).

neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies · score 0.75
genetic disorder · score 0.49
Neurodevelopmental delay · score 0.33
neurodegenerative disease · score 0.27
monocyte count · score 0.19
Global developmental delay · score 0.15
Dandy-Walker syndrome · score 0.15
blood protein measurement · score 0.14
hepatocellular carcinoma · score 0.08
platelet component distribution width · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N201-F1	alphafold	PREDICTED	74.83	—

Amino-acid sequence (2190 residues)

MNRAKPTTVR RPSAAAKPSG HPPPGDFIAL GSKGQANESK TASTLLKPAP SGLPSERKRD AAAALSSASA LTGLTKRPKL SSTPPLSALG RLAEAAVAEK RAISPSIKEP SVVPIEVLPT VLLDEIEAAE LEGNDDRIEG VLCGAVKQLK VTRAKPDSTL YLSLMYLAKI KPNIFATEGV IEALCSLLRR DASINFKAKG NSLVSVLACN LLMAAYEEDE NWPEIFVKVY IEDSLGERIW VDSPHCKTFV DNIQTAFNTR MPPRSVLLQG EAGRVAGDLG AGSSPHPSLT EEEDSQTELL IAEEKLSPEQ EGQLMPRYEE LAESVEEYVL DMLRDQLNRR QPIDNVSRNL LRLLTSTCGY KEVRLLAVQK LEMWLQNPKL TRPAQDLLMS VCMNCNTHGS EDMDVISHLI KIRLKPKVLL NHFMLCIREL LSAHKDNLGT TIKLVIFNEL SSARNPNNMQ VLYTALQHSS ELAPKFLAMV FQDLLTNKDD YLRASRALLR EIIKQTKHEI NFQAFCLGLM QERKEPQYLE MEFKERFVVH ITDVLAVSMM LGITAQVKEA GIAWDKGEKR NLEVLRSFQN QIAAIQRDAV WWLHTVVPSI SKLAPKDYVH CLHKVLFTEQ PETYYKWDNW PPESDRNFFL RLCSEVPILE DTLMRILVIG LSRELPLGPA DAMELADHLV KRAAAVQADD VEVLKVGRTQ LIDAVLNLCT YHHPENIQLP PGYQPPNLAI STLYWKAWPL LLVVAAFNPE NIGLAAWEEY PTLKMLMEMV MTNNYSYPPC TLTDEETRTE MLNRELQTAQ REKQEILAFE GHLAAASTKQ TITESSSLLL SQLTSLDPQG PPRRPPPHIL DQVKSLNQSL RLGHLLCRSR NPDFLLHIIQ RQASSQSMPW LADLVQSSEG SLDVLPVQCL CEFLLHDAVD DAASGEEDDE GESKEQKAKK RQRQQKQRQL LGRLQDLLLG PKADEQTTCE VLDYFLRRLG SSQVASRVLA MKGLSLVLSE GSLRDGEEKE PPMEEDVGDT DVLQGYQWLL RDLPRLPLFD SVRSTTALAL QQAIHMETDP QTISAYLIYL SQHTPVEEQA QHSDLALDVA RLVVERSTIM SHLFSKLSPS AASDAVLSAL LSIFSRYVRR MRQSKEGEEV YSWSESQDQV FLRWSSGETA TMHILVVHAM VILLTLGPPR ADDSEFQALL DIWFPEEKPL PTAFLVDTSE EALLLPDWLK LRMIRSEVLR LVDAALQDLE PQQLLLFVQS FGIPVSSMSK LLQFLDQAVA HDPQTLEQNI MDKNYMAHLV EVQHERGASG GQTFHSLLTA SLPPRRDSTE APKPKSSPEQ PIGQGRIRVG TQLRVLGPED DLAGMFLQIF PLSPDPRWQS SSPRPVALAL QQALGQELAR VVQGSPEVPG ITVRVLQALA TLLSSPHGGA LVMSMHRSHF LACPLLRQLC QYQRCVPQDT GFSSLFLKVL LQMLQWLDSP GVEGGPLRAQ LRMLASQASA GRRLSDVRGG LLRLAEALAF RQDLEVVSST VRAVIATLRS GEQCSVEPDL ISKVLQGLIE VRSPHLEELL TAFFSATADA ASPFPACKPV VVVSSLLLQE EEPLAGGKPG ADGGSLEAVR LGPSSGLLVD WLEMLDPEVV SSCPDLQLRL LFSRRKGKGQ AQVPSFRPYL LTLFTHQSSW PTLHQCIRVL LGKSREQRFD PSASLDFLWA CIHVPRIWQG RDQRTPQKRR EELVLRVQGP ELISLVELIL AEAETRSQDG DTAACSLIQA RLPLLLSCCC GDDESVRKVT EHLSGCIQQW GDSVLGRRCR DLLLQLYLQR PELRVPVPEV LLHSEGAASS SVCKLDGLIH RFITLLADTS DSRALENRGA DASMACRKLA VAHPLLLLRH LPMIAALLHG RTHLNFQEFR QQNHLSCFLH VLGLLELLQP HVFRSEHQGA LWDCLLSFIR LLLNYRKSSR HLAAFINKFV QFIHKYITYN APAAISFLQK HADPLHDLSF DNSDLVMLKS LLAGLSLPSR DDRTDRGLDE EGEEESSAGS LPLVSVSLFT PLTAAEMAPY MKRLSRGQTV EDLLEVLSDI DEMSRRRPEI LSFFSTNLQR LMSSAEECCR NLAFSLALRS MQNSPSIAAA FLPTFMYCLG SQDFEVVQTA LRNLPEYALL CQEHAAVLLH RAFLVGMYGQ MDPSAQISEA LRILHMEAVM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards