Nesprin-4 (SYNE4)

About Nesprin-4

Nesprin-4 (SYNE4) is a protein from Homo sapiens identified by UniProt accession Q8N205, 404 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.

Target properties

Protein name	Nesprin-4
UniProt accession	Q8N205
Gene	SYNE4
Organism	Homo sapiens
Length	404 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (16)

Diseases linked to this target (Open Targets).

deafness · score 0.56
hearing loss, autosomal recessive · score 0.56
nonsyndromic genetic hearing loss · score 0.48
autosomal dominant nonsyndromic hearing loss · score 0.44
Rare genetic deafness · score 0.27
pancreatic adenocarcinoma · score 0.04
ovarian carcinoma · score 0.02
clear cell renal carcinoma · score 0.01
neoplasm · score 0.01
cancer · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N205-F1	alphafold	PREDICTED	57.21	—

Amino-acid sequence (404 residues)

MALSLPLGPR LGSEPLNHPP GAPREADIVG CTVCPASGEE STSPEQAQTL GQDSLGPPEH FQGGPRGNEP AAHPPRWSTP SSYEDPAGGK HCEHPISGLE VLEAEQNSLH LCLLGLGRRL QDLEQGLGHW ALAQSGMVQL QALQVDLRGA AERVEALLAF GEGLAQRSEP RAWAALEQIL RALGAYRDSI FRRLWQLQAQ LVSYSLVFEE ANTLDQDLEV EGDSDWPGPG GVWGPWAPSS LPTSTELEWD PAGDIGGLGP LGQKTARTLG VPCELCGQRG PQGRGQGLEE ADTSHSRQDM LESGLGHQKR LARHQRHSLL RKPQDKKRQA SPHLQDVRLE GNPGAPDPAS RQPLTFLLIL FLLFLLLVGA MFLLPASGGP CCSHARIPRT PYLVLSYVNG LPPV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards