About Kelch-like protein 34
Kelch-like protein 34 (KLHL34) is a protein
from Homo sapiens identified by UniProt accession
Q8N239, 644 residues long.
MolForge cross-references it against 0 known binders and
10 disease associations.
Target properties
| Protein name | Kelch-like protein 34 |
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| UniProt accession | Q8N239 |
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| Gene | KLHL34 |
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| Organism | Homo sapiens |
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| Length | 644 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N239-F1 | alphafold | PREDICTED | 86.99 | — |
Amino-acid sequence (644 residues)
MSYFLSYCKA HGGALLTGYQ ALRAEGFLCD VTLETEGSEF PAHRSLLACS SDYFRALFKS HTQESRARVI HLHVPSAAGL QRLLDFIYTA WLSLSMDTVE DTLEAASYLQ VTEALGLCGR YLERQLAPEN CCFAANVAAR FGLAHTLDAA ERCIVSHLQE LLARGAGPAG LLELNPTSLR AVLGAPDVAR VPEARLLGLA LAWLRQEPTT ERLAHCTELL ERVRFGLVPA DVLRRVYSGS GLVLPARVKG LIIQALNYHT TPSRQPLMQG EQTSIRSPQT RILLVGGRRA REVVIEEVAA PQRAARGQVA APEPEEEEEE LEEEEEEEEW ELTQNVVAFD VYNHRWRSLT QLPTPLLGHS VCTAGNFLFV LGGESPSGSA SSPLADDSRV VTAQVHRYDP RFHAWTEVPA MREARAHFWC GAVGERLLAV GGLGAGGEVL ASVEMYDLRR DRWTAAGALP RALHGHAGAV GDRGVVYISG GKAGRGEGGA SSLRDLYVLG PEEQVWSKKA PMGTARFGHH MAVLRGAVFA FLGRYEPFSE IERYDPGADQ WTRLRPLPYD RFCYGLAVVE ETALLLGGLK WRDSRQVPTR NVVGYDLDLD RWEDIGCALP WAWSGLRCAV LQLAEGGDDE REGEVGEALD LVLG
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