About Protein unc-80 homolog
Protein unc-80 homolog (UNC80) is a protein
from Homo sapiens identified by UniProt accession
Q8N2C7, 3258 residues long.
MolForge cross-references it against 0 known binders and
59 disease associations.
Target properties
| Protein name | Protein unc-80 homolog |
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| UniProt accession | Q8N2C7 |
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| Gene | UNC80 |
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| Organism | Homo sapiens |
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| Length | 3258 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (59)
Diseases linked to this target (Open Targets).
- hypotonia, infantile, with psychomotor retardation and characteristic facies · score 0.76
- Encephalopathy · score 0.36
- Neurodevelopmental delay · score 0.33
- glomerular filtration rate · score 0.33
- creatinine measurement · score 0.30
- Intellectual disability · score 0.27
- Moderate global developmental delay · score 0.27
- brain measurement · score 0.23
- anxiety · score 0.22
- smoking behaviour measurement · score 0.22
3D Structure (10)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Amino-acid sequence (3258 residues)
MVKRKSSEGQ EQDGGRGIPL PIQTFLWRQT SAFLRPKLGK QYEASCVSFE RVLVENKLHG LSPALSEAIQ SISRWELVQA ALPHVLHCTA TLLSNRNKLG HQDKLGVAET KLLHTLHWML LEAPQDCNNE RFGGTDRGSS WGGSSSAFIH QVENQGSPGQ PCQSSSNDEE ENNRRKIFQN SMATVELFVF LFAPLVHRIK ESDLTFRLAS GLVIWQPMWE HRQPGVSGFT ALVKPIRNII TAKRSSPINS QSRTCESPNQ DARHLEGLQV VCETFQSDSI SPKATISGCH RGNSFDGSLS SQTSQERGPS HSRASLVIPP CQRSRYATYF DVAVLRCLLQ PHWSEEGTQW SLMYYLQRLR HMLEEKPEKP PEPDIPLLPR PRSSSMVAAA PSLVNTHKTQ DLTMKCNEEE KSLSSEAFSK VSLTNLRRSA VPDLSSDLGM NIFKKFKSRK EDRERKGSIP FHHTGKRRPR RMGVPFLLHE DHLDVSPTRS TFSFGSFSGL GEDRRGIEKG GWQTTILGKL TRRGSSDAAT EMESLSARHS HSHHTLVSDL PDPSNSHGEN TVKEVRSQIS TITVATFNTT LASFNVGYAD FFNEHMRKLC NQVPIPEMPH EPLACANLPR SLTDSCINYS YLEDTEHIDG TNNFVHKNGM LDLSVVLKAV YLVLNHDISS RICDVALNIV ECLLQLGVVP CVEKNRKKSE NKENETLEKR PSEGAFQFKG VSGSSTCGFG GPAVSGAGDG GGEEGGGGDG GGGGGDGGGG GGGGGGPYEK NDKNQEKDES TPVSNHRLAL TMLIKIVKSL GCAYGCGEGH RGLSGDRLRH QVFRENAQNC LTKLYKLDKM QFRQTMRDYV NKDSLNNVVD FLHALLGFCM EPVTDNKAGF GNNFTTVDNK STAQNVEGII VSAMFKSLIT RCASTTHELH SPENLGLYCD IRQLVQFIKE AHGNVFRRVA LSALLDSAEK LAPGKKVEEN EQESKPAGSK RSEAGSIVDK GQVSSAPEEC RSFMSGRPSQ TPEHDEQMQG ANLGRKDFWR KMFKSQSAAS DTSSQSEQDT SECTTAHSGT TSDRRARSRS RRISLRKKLK LPIGKRNWLK RSSLSGLADG VEDLLDISSV DRLSFIRQSS KVKFTSAVKL SEGGPGSGME NGRDEEENFF KRLGCHSFDD HLSPNQDGGK SKNVVNLGAI RQGMKRFQFL LNCCEPGTIP DASILAAALD LEAPVVARAA LFLECARFVH RCNRGNWPEW MKGHHVNITK KGLSRGRSPI VGNKRNQKLQ WNAAKLFYQW GDAIGVRLNE LCHGESESPA NLLGLIYDEE TKRRLRKEDE EEDFLDDSTV NPSKCGCPFA LKMAACQLLL EITTFLRETF SCLPRPRTEP LVDLESCRLR LDPELDRHRY ERKISFAGVL DENEDSKDSL HSSSHTLKSD AGVEEKKEGS PWSASEPSIE PEGMSNAGAE ENYHRNMSWL HVMILLCNQQ SFICTHVDYC HPHCYLHHSR SCARLVRAIK LLYGDSVDSL RESSNISSVA LRGKKQKECS DKSCLRTPSL KKRVSDANLE GKKDSGMLKY IRLQVMSLSP APLSLLIKAA PILTEEMYGD IQPAAWELLL SMDEHMAGAA AAMFLLCAVK VPEAVSDMLM SEFHHPETVQ RLNAVLKFHT LWRFRYQVWP RMEEGAQQIF KIPPPSINFT LPSPVLGMPS VPMFDPPWVP QCSGSVQDPI NEDQSKSFSA RAVSRSHQRA EHILKNLQQE EEKKRLGREA SLITAIPITQ EACYEPTCTP NSEPEEEVEE VTNLASRRLS VSPSCTSSTS HRNYSFRRGS VWSVRSAVSA EDEEHTTEHT PNHHVPQPPQ AVFPACICAA VLPIVHLMED GEVREDGVAV SAVAQQVLWN CLIEDPSTVL RHFLEKLTIS NRQDELMYML RKLLLNIGDF PAQTSHILFN YLVGLIMYFV RTPCEWGMDA ISATLTFLWE VVGYVEGLFF KDLKQTMKKE QCEVKLLVTA SMPGTKTLVV HGQNECDIPT QLPVHEDTQF EALLKECLEF FNIPESQSTH YFLMDKRWNL IHYNKTYVRD IYPFRRSVSP QLNLVHMHPE KGQELIQKQV FTRKLEEVGR VLFLISLTQK IPTAHKQSHV SMLQEDLLRL PSFPRSAIDA EFSLFSDPQA GKELFGLDTL QKSLWIQLLE EMFLGMPSEF PWGDEIMLFL NVFNGALILH PEDSALLRQY AATVINTAVH FNHLFSLSGY QWILPTMLQV YSDYESNPQL RQAIEFACHQ FYILHRKPFV LQLFASVAPL LEFPDAANNG PSKGVSAQCL FDLLQSLEGE TTDILDILEL VKAEKPLKSL DFCYGNEDLT FSISEAIKLC VTVVAYAPES FRSLQMLMVL EALVPCYLQK LKRQTSQVET VPAAREEIAA TAALATSLQA LLYSVEVLTR PMTAPQMSRC DQGHKGTTTA NHTMSSGVNT RYQEQGAKLH FIRENLHLLE EGQGIPREEL DERIAREEFR RPRESLLNIC TEFYKHCGPR LKILQNLAGE PRVIALELLD VKSHMRLAEI AHSLLKLAPY DTQTMESRGL RRYIMEMLPI TDWTAEAVRP ALILILKRLD RMFNKIHKMP TLRRQVEWEP ASNLIEGVCL TLQRQPIISF LPHLRSLINV CVNLVMGVVG PSSVADGLPL LHLSPYLSPP LPFSTAVVRL VALQIQALKE DFPLSHVISP FTNQERREGM LLNLLIPFVL TVGSGSKDSP WLEQPEVQLL LQTVINVLLP PRIISTSRSK NFMLESSPAH CSTPGDAGKD LRREGLAEST SQAAYLALKV ILVCFERQLG SQWYWLSLQV KEMALRKVGG LALWDFLDFI VRTRIPIFVL LRPFIQCKLL AQPAENHEEL SARQHIADQL ERRFIPRPLC KSSLIAEFNS ELKILKEAVH SGSAYQGKTS ISTVGTSTSA YRLSLATMSR SNTGTGTVWE QDSEPSQQAS QDTLSRTDEE DEENDSISMP SVVSEQEAYL LSAIGRRRFS SHVSSMSVPQ AEVGMLPSQS EPNVLDDSQG LAAEGSLSRV ASIQSEPGQQ NLLVQQPLGR KRGLRQLRRP LLSRQKTQTE PRNRQGARLS TTRRSIQPKT KPSADQKRSV TFIEAQPEPA AAPTDALPAT GQLQGCSPAP SRKPEAMDEP VLTSSPAIVV ADLHSVSPKQ SENFPTEEGE KEEDTEAQGA TAHSPLSAQL SDPDDFTGLE TSSLLQHGDT VLHISEENGM ENPLLSSQFT FTPTELGKTD AVLDESHV
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