Zinc finger protein 619 (ZNF619)

About Zinc finger protein 619

Zinc finger protein 619 (ZNF619) is a protein from Homo sapiens identified by UniProt accession Q8N2I2, 560 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.

Target properties

Protein name	Zinc finger protein 619
UniProt accession	Q8N2I2
Gene	ZNF619
Organism	Homo sapiens
Length	560 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (19)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.47
multiple sclerosis · score 0.28
lysosomal storage disease · score 0.28
Alzheimer disease · score 0.28
Parkinson disease · score 0.28
eosinophil percentage of leukocytes · score 0.16
colorectal cancer · score 0.14
eosinophil count · score 0.11
blood protein measurement · score 0.10
colorectal adenoma · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N2I2-F1	alphafold	PREDICTED	60.43	—

Amino-acid sequence (560 residues)

MGQPAPYAEG PIQGGDAGEL CKCDFLVSIS IPQTRSDIPA GARRSSMGPR SLDTCWGRGP ERHVHRLECN GVIFTHRNLC LPGGKTKTEN EEKTAQLNIS KESESHRLIV EGLLMDVPQH PDFKDRLEKS QLHDTGNKTK IGDCTDLTVQ DHESSTTERE EIARKLEESS VSTHLITKQG FAKEQVFYKC GECGSYYNPH SDFHLHQRVH TNEKPYTCKE CGKTFRYNSK LSRHQKIHTG EKPYSCEECG QAFSQNSHLL QHQKLHGGQR PYECTDCGKT FSYNSKLIRH QRIHTGEKPF KCKECGKAFS CSYDCIIHER IHNGEKPYEC KECGKSLSSN SVLIQHQRIH TGEKPYECKE CGKAFHRSSV FLQHQRFHTG EQLYKCNECW KTFSCSSRFI VHQRIHNGEK PYECQECGKT FSQKITLVQH QRVHTGEKPY ECKECGKAFR WNASFIQHQK WHTRKKLING TGLSAVKPYC PCAILSPLPP QHTCSALAPP GPPLSSSHAV VLPPSVPFFL LLPSSEKANP SPVQIAHFFQ DLAFPGKSSL QSPNPLSHSL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards