About Lysoplasmalogenase TMEM86A
Lysoplasmalogenase TMEM86A (TMEM86A) is a protein
from Homo sapiens identified by UniProt accession
Q8N2M4, 240 residues long.
MolForge cross-references it against 0 known binders and
55 disease associations.
Target properties
| Protein name | Lysoplasmalogenase TMEM86A |
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| UniProt accession | Q8N2M4 |
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| Gene | TMEM86A |
|---|
| Organism | Homo sapiens |
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| Length | 240 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (55)
Diseases linked to this target (Open Targets).
- alcohol dependence · score 0.12
- risky sexual behaviour measurement · score 0.12
- Gollop-Wolfgang complex · score 0.06
- tibial hemimelia · score 0.06
- tibia, hypoplasia or aplasia of, with polydactyly · score 0.06
- fibular aplasia-ectrodactyly syndrome · score 0.06
- Blount disease · score 0.06
- metaphyseal anadysplasia · score 0.05
- acromesomelic dysplasia 2B · score 0.05
- brachydactyly-preaxial hallux varus syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N2M4-F1 | alphafold | PREDICTED | 90.17 | — |
Amino-acid sequence (240 residues)
MVSPVTVVKS EGPKLVPFFK ATCVYFVLWL PSSSPSWVST LIKCLPIFCL WLFLLAHGLG FLLAHPSATR IFVGLVFSAV GDAFLIWQDQ GYFVHGLLMF AVTHMFYASA FGMQPLALRT GLVMAALSGL CYALLYPCLS GAFTYLVGVY VALIGFMGWR AMAGLRLAGA DWRWTELAAG SGALFFIISD LTIALNKFCF PVPYSRALIM STYYVAQMLV ALSAVESREP VEHYRLTKAN
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