About CLK4-associating serine/arginine rich protein
CLK4-associating serine/arginine rich protein (CLASRP) is a protein
from Homo sapiens identified by UniProt accession
Q8N2M8, 674 residues long.
MolForge cross-references it against 0 known binders and
24 disease associations.
Target properties
| Protein name | CLK4-associating serine/arginine rich protein |
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| UniProt accession | Q8N2M8 |
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| Gene | CLASRP |
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| Organism | Homo sapiens |
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| Length | 674 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (24)
Diseases linked to this target (Open Targets).
- apolipoprotein B measurement · score 0.23
- low density lipoprotein cholesterol measurement · score 0.21
- C-reactive protein measurement · score 0.18
- alkaline phosphatase measurement · score 0.16
- total cholesterol measurement · score 0.15
- Alzheimer disease · score 0.12
- neoplasm · score 0.03
- secondary progressive multiple sclerosis · score 0.01
- nonpapillary renal cell carcinoma · score 0.01
- non-small cell lung carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N2M8-F1 | alphafold | PREDICTED | 58.72 | — |
Amino-acid sequence (674 residues)
MWHEARKHER KLRGMMVDYK KRAERRREYY EKIKKDPAQF LQVHGRACKV HLDSAVALAA ESPVNMMPWQ GDTNNMIDRF DVRAHLDHIP DYTPPLLTTI SPEQESDERK CNYERYRGLV QNDFAGISEE QCLYQIYIDE LYGGLQRPSE DEKKKLAEKK ASIGYTYEDS TVAEVEKAAE KPEEEESAAE EESNSDEDEV IPDIDVEVDV DELNQEQVAD LNKQATTYGM ADGDFVRMLR KDKEEAEAIK HAKALEEEKA MYSGRRSRRQ RREFREKRLR GRKISPPSYA RRDSPTYDPY KRSPSESSSE SRSRSRSPTP GREEKITFIT SFGGSDEEAA AAAAAAAASG VTTGKPPAPP QPGGPAPGRN ASARRRSSSS SSSSSASRTS SSRSSSRSSS RSRRGGGYYR SGRHARSRSR SWSRSRSRSR RYSRSRSRGR RHSGGGSRDG HRYSRSPARR GGYGPRRRSR SRSHSGDRYR RGGRGLRHHS SSRSRSSWSL SPSRSRSLTR SRSHSPSPSQ SRSRSRSRSQ SPSPSPAREK LTRPAASPAV GEKLKKTEPA AGKETGAAKP KLTPQEKLKL RMQKALNRQF KADKKAAQEK MIQQEHERQE REDELRAMAR KIRMKERERR EKEREEWERQ YSRQSRSPSP RYSREYSSSR RRSRSRSRSP HYRH
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