Small vasohibin-binding protein (SVBP)

About Small vasohibin-binding protein

Small vasohibin-binding protein (SVBP) is a protein from Homo sapiens identified by UniProt accession Q8N300, 66 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.

Target properties

Protein name	Small vasohibin-binding protein
UniProt accession	Q8N300
Gene	SVBP
Organism	Homo sapiens
Length	66 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (30)

Diseases linked to this target (Open Targets).

neurodevelopmental disorder with ataxia, hypotonia, and microcephaly · score 0.62
Microcephaly · score 0.43
Intellectual disability · score 0.43
Lower limb spasticity · score 0.43
complex neurodevelopmental disorder · score 0.37
genetic disorder · score 0.17
serum gamma-glutamyl transferase measurement · score 0.08
Polymicrogyria due to TUBB2B mutation · score 0.05
Red cell distribution width · score 0.04
Genetic central nervous system malformation · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N300-F1	alphafold	PREDICTED	85.08	—

Amino-acid sequence (66 residues)

MDPPARKEKT KVKESVSRVE KAKQKSAQQE LKQRQRAEIY ALNRVMTELE QQQFDEFCKQ MQPPGE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards