About Leucine-rich repeat-containing protein 43
Leucine-rich repeat-containing protein 43 (LRRC43) is a protein
from Homo sapiens identified by UniProt accession
Q8N309, 656 residues long.
MolForge cross-references it against 0 known binders and
49 disease associations.
Target properties
| Protein name | Leucine-rich repeat-containing protein 43 |
|---|
| UniProt accession | Q8N309 |
|---|
| Gene | LRRC43 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 656 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (49)
Diseases linked to this target (Open Targets).
- Eczematoid dermatitis · score 0.33
- allergic rhinitis · score 0.30
- asthma · score 0.25
- psoriasis · score 0.24
- neurodermatitis · score 0.24
- prurigo · score 0.24
- grip strength measurement · score 0.24
- seasonal allergic rhinitis · score 0.21
- neurodegenerative disease · score 0.16
- body height · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N309-F1 | alphafold | PREDICTED | 74.59 | — |
Amino-acid sequence (656 residues)
MEASYESESE SESEAGPGTQ RPGTGTVSAA VREHLRKLCL REFPCGAGSW NKSRFLPQTW RTWRELVPRE EDVVSPGEET VEALLGLVRS RHSPWALLNN SNAEDSFLRE LAIRNPLTIT DTFFYSYFRS LRVIDKKVTL VDKDLLKFLK LEELVLSANR IKEVDATNLP PTLKVLELYG NEISSMECLC AHPPAGLQHL GLGHNKLLGP LESLYVTANH WPNLVSLDLG FNDLTDLQSM VTSLRTLRHL RLLVLQGNPL ALVPYYRGLT IDSLAQLCVL DDITVSPNEK HLFRGLSLNG DLLAQEAQFV VTIGNIRGVL DTSVLDPEPR PEGPFITYNY YVTYDFVKDE EGEMNESAGV LAEIVKPSPS LELLVEESPE EVVEDVIEDI VEEVTEEVEG SLESEVEESG ESELSVISGP STILQMPRAS AEELAKLRLR IDPRLCPSPG TVLFSTAHKP WAEVIPCSYE MQHSLRDLVP LKAFLLAGTT VTIVEEKILS WPVVLPAVDS PLSAKKGKGE KDKKGKEKDR TGKGEKEPAK EWKVLKKKKE PPKELRQDPP ILQVLGRGLV ILEPLLAGEP LVSTVCNFGV VRTLTSDRLT LARDSKKIKK VAKKEKPKAV IPIYEGDYHP EPLTVEVQIQ LNQCRSAEEA LRMFAV
Explore Leucine-rich repeat-containing protein 43 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets