About Voltage-dependent calcium channel beta subunit-associated regulatory protein
Voltage-dependent calcium channel beta subunit-associated regulatory protein (CBARP) is a protein
from Homo sapiens identified by UniProt accession
Q8N350, 705 residues long.
MolForge cross-references it against 0 known binders and
46 disease associations.
Target properties
| Protein name | Voltage-dependent calcium channel beta subunit-associated regulatory protein |
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| UniProt accession | Q8N350 |
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| Gene | CBARP |
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| Organism | Homo sapiens |
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| Length | 705 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (46)
Diseases linked to this target (Open Targets).
- creatinine measurement · score 0.29
- Peutz-Jeghers syndrome · score 0.16
- diet measurement · score 0.11
- cystatin C measurement · score 0.10
- lymphocyte count · score 0.09
- lymphocyte percentage of leukocytes · score 0.08
- type 2 diabetes mellitus · score 0.08
- PR interval · score 0.06
- mean corpuscular hemoglobin · score 0.05
- behavioral variant of frontotemporal dementia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N350-F1 | alphafold | PREDICTED | 51.30 | — |
Amino-acid sequence (705 residues)
MQPTATMATA ATTTTTTTAT VALTTSWDNA TGRPTAEPDP ILDNYVLLVV VMSLFVGGTL VVLSGVLLLC KRCWDVHQRL NRAMEEAEKT TTTYLDNGTH PAQDPDFRGE DPECQDAETE RFLSTSSTGR RVSFNEAALF EQSRKTQDKG RRYTLTEGDF HHLKNARLTH LHLPPLKIVT IHECDSGEAS SATTPHPATS PKATLAIFQP PGKALTGRSV GPSSALPGDP YNSAAGATDF AEISPSASSD SGEGTSLDAG TRSTKAGGPG AAAGPGEAGP GSGAGTVLQF LTRLRRHASL DGASPYFKVK KWKLEPSQRA ASLDTRGSPK RHHFQRQRAA SESTEQEEGD APQEDFIQYI ARAGDAVAFP HPRPFLASPP PALGRLEAAE AAGGASPDSP PERGAGSAGP EQQQPPLEPD AERDAGPEQA QTSYRDLWSL RASLELHAAA SDHSSSGNDR DSVRSGDSSG SGSGGAAPAF PPPSPPAPRP KDGEARRLLQ MDSGYASIEG RGAGDDTEPP AAPARPRSPR AWPRRPRRDY SIDEKTDALF HEFLRHDPHF DDTPAAARHR ARAHPHARKQ WQRGRQHSDP GARAAPALAG TPAPPAGAAR PARAPLRRGD SVDGPPDGRT LGGAGDDPAI PVIEEEPGGG GCPGSGLCVL PSGSVLDKLA AGLDERLFPP RLAEPVVATP ALVAAAPTSP DHSPA
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