Circadian-associated transcriptional repressor (CIART)

About Circadian-associated transcriptional repressor

Circadian-associated transcriptional repressor (CIART) is a protein from Homo sapiens identified by UniProt accession Q8N365, 385 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.

Target properties

Protein name	Circadian-associated transcriptional repressor
UniProt accession	Q8N365
Gene	CIART
Organism	Homo sapiens
Length	385 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (46)

Diseases linked to this target (Open Targets).

Red cell distribution width · score 0.15
appendicular lean mass · score 0.12
basophil count · score 0.09
creatinine measurement · score 0.09
neutrophil count · score 0.09
circadian rhythm · score 0.07
leukocyte count · score 0.06
asthma · score 0.06
glomerular filtration rate · score 0.06
low density lipoprotein cholesterol measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N365-F1	alphafold	PREDICTED	54.53	—

Amino-acid sequence (385 residues)

MDSPSSVSSY SSYSLSSSFP TSPVNSDFGF PSDSEREDKG AHGPRPDTVG QRGGSRPSPG PIRCRHRSKV SGNQHTPSHP KQRGSASPMA GSGAKRSRDG ELETSLNTQG CTTEGDLLFA QKCKELQGFI PPLTDLLNGL KMGRFERGLS SFQQSVAMDR IQRIVGVLQK PQMGERYLGT LLQVEGMLKT WFPQIAAQKS SLGGGKHQLT KHFPSHHSDS AASSPASPME KMDQTQLGHL ALKPKQPWHL TQWPAMNLTW IHTTPICNPP LSSPGTISFS HGPLGTGTGI GVILFLQHGV QPFTHSAPTT PVPPTTASPV IPGEPMKLSG EGPRCYSLPV TLPSDWSYTL SPPSLPTLAR KMTIGHREQQ RSHPPVAADA HLLNL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards