About Large neutral amino acids transporter small subunit 4
Large neutral amino acids transporter small subunit 4 (SLC43A2) is a protein
from Homo sapiens identified by UniProt accession
Q8N370, 569 residues long.
MolForge cross-references it against 0 known binders and
51 disease associations.
Target properties
| Protein name | Large neutral amino acids transporter small subunit 4 |
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| UniProt accession | Q8N370 |
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| Gene | SLC43A2 |
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| Organism | Homo sapiens |
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| Length | 569 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (51)
Diseases linked to this target (Open Targets).
- lean body mass · score 0.27
- appendicular lean mass · score 0.20
- creatinine measurement · score 0.20
- reticulocyte count · score 0.20
- reticulocyte measurement · score 0.19
- diabetes mellitus · score 0.19
- HbA1c measurement · score 0.11
- Umbilical hernia · score 0.09
- mean platelet volume · score 0.09
- platelet crit · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N370-F1 | alphafold | PREDICTED | 78.88 | — |
Amino-acid sequence (569 residues)
MAPTLATAHR RRWWMACTAV LENLLFSAVL LGWGSLLIML KSEGFYSYLC TEPENVTNGT VGGTAEPGHE EVSWMNGWLS CQAQDEMLNL AFTVGSFLLS AITLPLGIVM DKYGPRKLRL LGSACFAVSC LLIAYGASKP NALSVLIFIA LALNGFGGMC MTFTSLTLPN MFGDLRSTFI ALMIGSYASS AVTFPGIKLI YDAGVSFIVV LVVWAGCSGL VFLNCFFNWP LEPFPGPEDM DYSVKIKFSW LGFDHKITGK QFYKQVTTVG RRLSVGSSMR SAKEQVALQE GHKLCLSTVD LEVKCQPDAA VAPSFMHSVF SPILLLSLVT MCVTQLRLIF YMGAMNNILK FLVSGDQKTV GLYTSIFGVL QLLCLLTAPV IGYIMDWRLK ECEDASEEPE EKDANQGEKK KKKRDRQIQK ITNAMRAFAF TNLLLVGFGV TCLIPNLPLQ ILSFILHTIV RGFIHSAVGG LYAAVYPSTQ FGSLTGLQSL ISALFALLQQ PLFLAMMGPL QGDPLWVNVG LLLLSLLGFC LPLYLICYRR QLERQLQQRQ EDDKLFLKIN GSSNQEAFV
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