Leucine-rich repeat-containing protein 25 (LRRC25)

About Leucine-rich repeat-containing protein 25

Leucine-rich repeat-containing protein 25 (LRRC25) is a protein from Homo sapiens identified by UniProt accession Q8N386, 305 residues long. MolForge cross-references it against 0 known binders and 100 disease associations.

Target properties

Protein name	Leucine-rich repeat-containing protein 25
UniProt accession	Q8N386
Gene	LRRC25
Organism	Homo sapiens
Length	305 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (100)

Diseases linked to this target (Open Targets).

HbA1c measurement · score 0.32
growth differentiation factor 15 measurement · score 0.30
neutrophil count · score 0.29
leukocyte count · score 0.25
monocyte percentage of leukocytes · score 0.25
myeloid white cell count · score 0.24
C-reactive protein measurement · score 0.23
blood protein measurement · score 0.23
Red cell distribution width · score 0.22
systemic lupus erythematosus · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N386-F1	alphafold	PREDICTED	70.30	—

Amino-acid sequence (305 residues)

MGGTLAWTLL LPLLLRESDS LEPSCTVSSA DVDWNAEFSA TCLNFSGLSL SLPHNQSLRA SNVILLDLSG NGLRELPVTF FAHLQKLEVL NVLRNPLSRV DGALAARCDL DLQADCNCAL ESWHDIRRDN CSGQKPLLCW DTTSSQHNLS AFLEVSCAPG LASATIGAVV VSGCLLLGLA IAGPVLAWRL WRCRVARSRE LNKPWAAQDG PKPGLGLQPR YGSRSAPKPQ VAVPSCPSTP DYENMFVGQP AAEHQWDEQG AHPSEDNDFY INYKDIDLAS QPVYCNLQSL GQAPMDEEEY VIPGH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards