About Protein O-mannosyl-transferase TMTC2
Protein O-mannosyl-transferase TMTC2 (TMTC2) is a protein
from Homo sapiens identified by UniProt accession
Q8N394, 836 residues long.
MolForge cross-references it against 0 known binders and
43 disease associations.
Target properties
| Protein name | Protein O-mannosyl-transferase TMTC2 |
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| UniProt accession | Q8N394 |
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| Gene | TMTC2 |
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| Organism | Homo sapiens |
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| Length | 836 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (43)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- heel bone mineral density · score 0.37
- brain measurement · score 0.33
- alcohol abuse · score 0.32
- cup-to-disc ratio measurement · score 0.28
- self reported educational attainment · score 0.26
- gut microbiome measurement · score 0.26
- ulcerative colitis · score 0.25
- optic cup area measurement · score 0.24
- optic disc area measurement · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N394-F1 | alphafold | PREDICTED | 90.36 | — |
Amino-acid sequence (836 residues)
MIAELVSSAL GLALYLNTLS ADFCYDDSRA IKTNQDLLPE TPWTHIFYND FWGTLLTHSG SHKSYRPLCT LSFRLNHAIG GLNPWSYHLV NVLLHAAVTG LFTSFSKILL GDGYWTFMAG LMFASHPIHT EAVAGIVGRA DVGASLFFLL SLLCYIKHCS TRGYSARTWG WFLGSGLCAG CSMLWKEQGV TVLAVSAVYD VFVFHRLKIK QILPTIYKRK NLSLFLSISL LIFWGSSLLG ARLYWMGNKP PSFSNSDNPA ADSDSLLTRT LTFFYLPTKN LWLLLCPDTL SFDWSMDAVP LLKTVCDWRN LHTVAFYTGL LLLAYYGLKS PSVDRECNGK TVTNGKQNAN GHSCLSDVEY QNSETKSSFA SKVENGIKND VSQRTQLPST ENIVVLSLSL LIIPFVPATN LFFYVGFVIA ERVLYIPSMG FCLLITVGAR ALYVKVQKRF LKSLIFYATA TLIVFYGLKT AIRNGDWQNE EMLYRSGIKV NPAKAWGNLG NVLKSQSKIS EAESAYRNAL YYRSNMADML YNLGLLLQEN SRFAEALHYY KLAIGSRPTL ASAYLNTGII LMNQGRTEEA RRTFLKCSEI PDENLKDPHA HKSSVTSCLY NLGKLYHEQG HYEEALSVYK EAIQKMPRQF APQSLYNMMG EAYMRLSKLP EAEHWYMESL RSKTDHIPAH LTYGKLLALT GRKSEAEKLF LKAIELDPTK GNCYMHYGQF LLEEARLIEA AEMAKKAAEL DSTEFDVVFN AAHMLRQASL NEAAEKYYDL AARLRPNYPA ALMNLGAILH LNGRLQKAEA NYLRALQLKP DDVITQSNLR KLWNIMEKQG LKTSKT
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