About von Willebrand factor A domain-containing protein 5B2
von Willebrand factor A domain-containing protein 5B2 (VWA5B2) is a protein
from Homo sapiens identified by UniProt accession
Q8N398, 1242 residues long.
MolForge cross-references it against 0 known binders and
19 disease associations.
Target properties
| Protein name | von Willebrand factor A domain-containing protein 5B2 |
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| UniProt accession | Q8N398 |
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| Gene | VWA5B2 |
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| Organism | Homo sapiens |
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| Length | 1242 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (19)
Diseases linked to this target (Open Targets).
- mathematical ability · score 0.18
- cortical thickness · score 0.18
- brain measurement · score 0.17
- neuroimaging measurement · score 0.12
- genetic disorder · score 0.12
- brain volume measurement · score 0.11
- hypertension · score 0.09
- cardiovascular disease · score 0.09
- blood pressure · score 0.08
- central nervous system cancer · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N398-F1 | alphafold | PREDICTED | 64.37 | — |
Amino-acid sequence (1242 residues)
MPGLYCPSSW TPLPLTDSWV RACANGPCLS VRARLTYRNP QPQPVDGVFV YPLAEAEVVS GFEAEAAGRR VSFQLQSRRR SQAACCRALG PGLGTPTPRR CAQGHLVLDL AQARSTLVLP TGIIAAAGTM TVTLHSSREL PSRPDGVLHV ALPTVLTPLA PPGPPGPPRP PGLCDDSPTS CFGVGSLQEE GLAWEELAAP RDVFSGPARC PAPYTFSFEM LVTGPCLLAG LESPSHALRA DAPPHASSAA TICVTLAEGH HCDRALEILL HPSEPHQPHL MLEGGSLSSA EYEARVRARR DFQRLQRRDS DGDRQVWFLQ RRFHKDILLN PVLALSFCPD LSSKPGHLGT ATRELLFLLD SSSVAHKDAI VLAVKSLPPQ TLINLAVFGT LVQPLFPESR PCSDDAVQLI CESIETLQVP SGPPDVLAAL DWAVGQPQHR AYPRQLFLLT AASPMAATTH RTLELMRWHR GTARCFSFGL GPTCHQLLQG LSALSRGQAY FLRPGQRLQP MLVQALRKAL EPALSDISVD WFVPDTVEAL LTPREIPALY PGDQLLGYCS LFRVDGFRSR PPGGQEPGWQ SSGGSVFPSP EEAPSAASPG TEPTGTSEPL GTGTVSAELS SPWAARDSEQ STDALTDPVT DPGPNPSDTA IWRRIFQSSY IREQYVLTHC SASPEPGPGS TGSSESPGSQ GPGSPEGSAP LEPPSQQGCR SLAWGEPAGS RSCPLPAPTP APFKVGALST EVLGRQHRAA LAGRSLSSPP GRANQVPGRP RKPSLGAILD GPSPEPGQQL GQGLDDSGNL LSPAPMDWDM LMEPPFLFTA VPPSGELAPP AVPPQAPRCH VVIRGLCGEQ PMCWEVGVGL ETLWGPGDGS QPPSPPVREA AWDQALHRLT AASVVRDNEQ LALRGGAETT ADRGHARRCW LRALQTSKVS SAPSCFTCPV AVDATTREVL PGALQVCSSE PAEPPGTPPA SHSHLDAAPL PTVVYSKGLQ RGSPAGAWDS DQNGNSKRAL GDPATPTEGP RRPPPRPPCR LSMGRRHKLC SPDPGQANNS EGSDHDYLPL VRLQEAPGSF RLDAPFCAAV RISQERLCRA SPFAVHRASL SPTSASLPWA LLGPGVGQGD SATASCSPSP SSGSEGPGQV DSGRGSDTEA SEGAEGLGGT DLRGRTWATA VALAWLEHRC AAAFDEWELT AAKADCWLRA QHLPDGLDLA ALKAAARGLF LLLRHWDQNL QLHLLCYSPA NV
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