Sperm-tail PG-rich repeat-containing protein 2 (STPG2)

About Sperm-tail PG-rich repeat-containing protein 2

Sperm-tail PG-rich repeat-containing protein 2 (STPG2) is a protein from Homo sapiens identified by UniProt accession Q8N412, 459 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.

Target properties

Protein name	Sperm-tail PG-rich repeat-containing protein 2
UniProt accession	Q8N412
Gene	STPG2
Organism	Homo sapiens
Length	459 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (23)

Diseases linked to this target (Open Targets).

adolescent idiopathic scoliosis · score 0.30
white matter microstructure measurement · score 0.29
risk-taking behaviour · score 0.27
intelligence · score 0.27
birth weight · score 0.27
cortical thickness · score 0.21
cortical surface area measurement · score 0.21
attention deficit hyperactivity disorder · score 0.18
smoking status measurement · score 0.18
antisocial behaviour measurement · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N412-F1	alphafold	PREDICTED	62.22	—

Amino-acid sequence (459 residues)

MYDRAPRLLK LAEGGSTEAH VGPGSYQVPF LKQQATGSNA PFLSLTARES TFTIASSIEK AVPGPGHYNV SEAQKISRSP TLTRSVDVPS IPSCGKSYGY HINDDGSIIK CFPPACDSTL GPAYYKPQFD VSNATLKYKG IHFGNSSGRQ ELPKKSGPGP GQYDIVQKKT SYYENVNIKR DQQQNYCSFI PRLYEIIVLQ EKKKRFLPMK SITPAPGTYN EPRTALKSLK KTSGLKNIPF GQSAVRFTQD IRTEEMPGPG FYNVLNNTII ASVRNICSKK QKKSAFGSSV PRTFFSVQKE ACATPGPADY QEFWHSQGVG ISDELPNLTN KYAAFLSRAK RTMKVPDMVI PAPGSYDVHK SYEMSQVKHK YMPPRSLVAK RKHASFLSAT PRCLEKVTDG PGPAAYNPVL RKSCPIPLFV KASKRFEESK EITPGPATYE ISQEKKKGNL IGEMAADIM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards